852948-13-1
852948-13-1
Chemical Structure
MB-07811
Synonym(s): VK-2809
- CAS No.: 852948-13-1
- Formula:C28H32ClO5P
- Molecular Weight:514.98
IUPAC Name: (2R,4S)-4-(3-chlorophenyl)-2-((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)-1,3,2-dioxaphosphinane 2-oxide
InChIKey: LGGPZDRLTDGYSQ-JADSYQMUSA-N
SMILES: OC1=CC=C(CC2=C(C)C=C(OC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C=C2C)C=C1C(C)C
Biological Activity: MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].
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MB-07811 | 99.75% | MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity. | ||||||||||||||||||||
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MB-07811 (Standard) | ≥98% | MB-07811 (Standard) is the analytical standard of MB-07811 (HY-111288). This product is intended for research and analytical applications. MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity. | ||||||||||||||||||||
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References
- [1]. Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. [Content Brief]
- [2]. Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. [Content Brief]
