1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. BMS453

BMS453 (Synonyms: BMS-189453)

Cat. No.: HY-100608 Purity: ≥98.0%
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BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

For research use only. We do not sell to patients.

BMS453 Chemical Structure

BMS453 Chemical Structure

CAS No. : 166977-43-1

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Description

BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2].

In Vitro

BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2].
BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest[2].
BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21[2].
BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Normal human mammary epithelial cells (184 and HMEC)
Concentration: 1 μM
Incubation Time: 11 hours
Result: Inhibited 3H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %.

Cell Cycle Analysis[2]

Cell Line: Normal human mammary epithelial cells (184 and HMEC)
Concentration: 1 μM
Incubation Time: 5 days
Result: Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase.

Western Blot Analysis[2]

Cell Line: 184 cells
Concentration: 1 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Induced Rb hypophosphorylation and decrease CDK2 kinase activity.
Molecular Weight

380.48

Formula

C₂₇H₂₄O₂

CAS No.

166977-43-1

SMILES

O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C4=CC=CC=C4)C3=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: ≥98.0%

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Keywords:

BMS453BMS-189453BMS 453BMS-453BMS189453BMS 189453RAR/RXRRetinoic acid receptorsRetinoid X receptorsG1arrestbreastcellRARβRARαRARγretinoidTGFβInhibitorinhibitorinhibit

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BMS453
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