166977-43-1
166977-43-1
Chemical Structure
BMS453
Synonym(s): BMS-189453
- CAS No.: 166977-43-1
- Formula:C27H24O2
- Molecular Weight:380.48
IUPAC Name: (E)-4-(2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid
InChIKey: VUODRPPTYLBGFM-CMDGGOBGSA-N
SMILES: O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C4=CC=CC=C4)C3=C2)C=C1
Biological Activity: BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2].
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BMS453 | 99.85% | BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. | ||||||||||||||||||||
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BMS453 (Standard) | ≥98% | BMS453 (Standard) is the analytical standard of BMS453 (HY-100608). This product is intended for research and analytical applications. BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. | ||||||||||||||||||||
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References
- [1]. J Y Chen, et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 Mar 15;14(6):1187-97. [Content Brief]
- [2]. L Yang, et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Oncogene. 2001 Nov 29;20(55):8025-35. [Content Brief]
Keywords
