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Results for "

543

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (2) Amino Acid Decarboxylase (2) Apoptosis (6) Autophagy (3) Bacterial (1) Bcl-2 Family (1) Cannabinoid Receptor (1) Carbonic Anhydrase (1) COX (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) EGFR (1) Epigenetic Reader Domain (1) Fluorescent Dye (10) GABA Receptor (1) Glycosidase (1) GPR55 (1) Histone Methyltransferase (1) HSP (1) JAK (1) Keap1-Nrf2 (1) Ligands for E3 Ligase (1) LPL Receptor (3) MicroRNA (12) NO Synthase (1) Notch (1) p38 MAPK (1) Parasite (1) PI3K (2) Potassium Channel (2) Prolyl Endopeptidase (PREP) (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) RET (1) SGLT (2) SphK (3) Tyrosinase (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (6) Infection (3) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (7)
Click Chemistry:	Azide (1)
Oligonucleotides:	miRNA mimics (3) miRNA antagomirs (3) miRNA agomirs (3) MicroRNAs (12) miRNA inhibitors (3)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15425

PF-543 20+ Cited Publications Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

HY-D1913

Fe2Orange Maximum Cited Publications 25 Publications Verification	Fluorescent Dye	Others
Fe2Orange is a Fe ²⁺ selective probe with an excitation wavelength of 543 nm and an emission wavelength of 580 nm. Fe2Orange emits fluorescence after binding to intracellular Fe ²⁺, thereby achieving specific labeling of Fe ²⁺. Fe2Orange is used to detect the content and distribution of Fe ²⁺ in cells .

HY-15096

MKT-077 15+ Cited Publications FJ-776	Fluorescent Dye HSP	Cancer
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

HY-15425A

*PF-543* Citrate** 20+ Cited Publications Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

HY-125959

Ucf-101 1 Publications Verification	Apoptosis	Cardiovascular Disease Neurological Disease
Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC₅₀ of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC₅₀>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .

HY-50856S

Deuruxolitinib CTP-543; Ruxolitinib d₈; Deuterated Ruxolitinib	JAK	Inflammation/Immunology
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata .

HY-D0304

Rhodamine B base Solvent red 49	Fluorescent Dye	Others
Rhodamine B base (Solvent red 49) is a fluorescent dye (Ex=543 nM; Em=565 nM) .

HY-D1157

HKPerox-2 5 Publications Verification	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-D1148

HKGreen-4I 1 Publications Verification	Fluorescent Dye	Others
HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of ONOO ^- in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-114289

6-HEX 1 Publications Verification	Fluorescent Dye	Others
6-HEX is one kind of light base group, the wave length is 532 nm, the wave length is 556 nm. 6-HEX can be used to record nucleic acid sequences and design optical materials. 6-HEX can be used to record nucleic acids at 543 nm radiation, and at 550 nm and 650 nm radiation (5 nm radiation), it can be used to directly locate the base of the cell group .

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Infection Neurological Disease
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-D1704

Bodipy TMR-X muscimol	GABA Receptor	Neurological Disease
Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations .

HY-100696

PNZ5	Epigenetic Reader Domain	Cancer
PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a K_D of 5.43 nM for BRD4(1) .

HY-158739

Rhodamine dithenoyl hydrazide	Fluorescent Dye	Cancer
Rhodamine dithenoyl hydrazide (probe 1) possesses excellent recognition and selectivity for Fe ³⁺ ion. Rhodamine dithenoyl hydrazide exhibits Excitation/Emission maxima of 543/550-700 nm, respectively .

HY-15425B

*PF-543* hydrochloride** Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

HY-P5396A

*GAD65 (524-543) acetate*	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-130022

HKPerox-1 2 Publications Verification	Fluorescent Dye	Others
HKPerox-1 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-122613

YM543 free base	SGLT	Metabolic Disease
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes .

HY-108590

DMP-543 XR-543	Potassium Channel	Neurological Disease
DMP-543 (XR-543) is a K_V7 channel blocker, also acts as a potent neurotransmitter release enhancer .

HY-146710

RET-IN-16	RET	Cancer
RET-IN-16 is a potent and selective RET inhibitor with IC₅₀s of 3.98 nM, 8.42 nM, 15.05 nM, 7.86 nM, 5.43 nM and 8.86 nM for RET(WT), RET(M918T), RET(V804L), RET(V804M), RET-CCDC6 and RET-KIF5B, respectively. RET-IN-16 has anticancer effects .

HY-141876

PRT543	Histone Methyltransferase Notch PI3K Akt Bcl-2 Family DNA/RNA Synthesis	Cancer
PRT543 is an orally active selective PRMT5 inhibitor. PRT543 reduces intracellular symmetric dimethylarginine (sDMA) levels, downregulates the expression of genes related to DNA damage repair and DNA replication pathways, and induces abnormal alternative splicing. PRT543 inhibits the MYB, NOTCH1 and PI3K/AKT signaling pathways, promotes nuclear translocation of FOXO1, upregulates the pro-apoptotic protein BAX, and enhances cellular sensitivity to BCL-2 inhibition. PRT543 disrupts the normal RNA splicing process and exerts a synthetic lethal effect on myeloid tumor cells carrying splicing factor mutations. PRT543 can be used in research related to various cancers including breast cancer, ovarian cancer and acute myeloid leukemia .

HY-103336

Tocrifluor 1117 T1117	GPR55 Cannabinoid Receptor	Cardiovascular Disease
Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251 (HY-15443), is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm) .

HY-15112

JTP-4819	Prolyl Endopeptidase (PREP)	Infection
JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC₅₀s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096) .

HY-125327

YM-543	SGLT	Metabolic Disease
YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.

HY-W953122

CRBN ligand-543	Ligands for E3 Ligase	Cancer
CRBN ligand-543 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-543 can be linked to a target protein ligand via a linker to form a PROTAC.

HY-R01626

*hsa-miR-543* mimic**	MicroRNA	Cancer
hsa-miR-543 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-543 mimic hsa-miR-543 mimic

HY-P5396

*GAD65 (524-543)*	Amino Acid Decarboxylase	Others
GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-R04514

*rno-miR-543-3p mimic*	MicroRNA	Cancer
rno-miR-543-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-543-3p mimic rno-miR-543-3p mimic

HY-R03291

*mmu-miR-543-5p mimic*	MicroRNA	Cancer
mmu-miR-543-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-543-5p mimic mmu-miR-543-5p mimic

HY-14526

5-DACTHF 543U76; 5,11-Methenyltetrahydrohomofolate	DNA/RNA Synthesis	Cancer
5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC₅₀: 3 and 94 μM). 5-DACTHF is a potent antitumor agent .

HY-RI03291A

*mmu-miR-543-5p antagomir*	MicroRNA	Cancer
mmu-miR-543-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-543-5p antagomir mmu-miR-543-5p antagomir

HY-125959R

Ucf-101 (Standard)	Apoptosis	Cardiovascular Disease Neurological Disease
Ucf-101 (Standard) is the analytical standard of Ucf-101. This product is intended for research and analytical applications. Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .

HY-112728

MMV024101	Parasite	Infection
MMV024101 shows potency against P. falciparum NF54 with an IC₅₀ value of 543 nM, which has antiplasmodial activity .

HY-108590R

*DMP-543* (Standard)** XR-543 (Standard)	Reference Standards Potassium Channel	Neurological Disease
DMP-543 (Standard) is the analytical standard of DMP-543 (HY-108590). This product is intended for research and analytical applications. DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer .

HY-169467

5-Chloro-α-methyltryptamine	5-HT Receptor Dopamine Receptor	Neurological Disease
5-Chloro-α-methyltryptamine (Compound 7b) is a potent and selective dual DA/5-HT releaser and 5-HT_2a agonist. 5-Chloro-α-methyltryptamine releases DA and 5-HT with the EC₅₀ values of 54.3 nM and 16.2 nM, respectively. 5-Chloro-α-methyltryptamine can be used in the study of neurotransmitter .

HY-W800770

*MB 543* DBCO**	Fluorescent Dye	Others
MB 543 DBCO is a fluroescent agent with a terminal DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. MB 543 Alkyne is a very hydrophilic, water-soluble, orange fluorescent dye that has a maximal absorption of 543 nm and emission at 566 nm. The compound is also pH insensitive from pH 3 to pH 10.

HY-180112

SH543	Keap1-Nrf2 Reactive Oxygen Species (ROS) PI3K Akt p38 MAPK	Metabolic Disease
SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor κB ligand (RANKL)-induced osteoclastogenesis with an IC₅₀ of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research .

HY-RI01626

*hsa-miR-543* inhibitor**	MicroRNA	Cancer
hsa-miR-543 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-543 inhibitor hsa-miR-543 inhibitor

HY-R01626A

*hsa-miR-543* agomir**	MicroRNA	Cancer
hsa-miR-543 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-543 agomir hsa-miR-543 agomir

HY-RI01626A

*hsa-miR-543* antagomir**	MicroRNA	Cancer
hsa-miR-543 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-543 antagomir hsa-miR-543 antagomir

HY-RI04514

*rno-miR-543-3p inhibitor*	MicroRNA	Cancer
rno-miR-543-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-543-3p inhibitor rno-miR-543-3p inhibitor

HY-RI03291

*mmu-miR-543-5p inhibitor*	MicroRNA	Cancer
mmu-miR-543-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-543-5p inhibitor mmu-miR-543-5p inhibitor

HY-R03291A

*mmu-miR-543-5p agomir*	MicroRNA	Cancer
mmu-miR-543-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-543-5p agomir mmu-miR-543-5p agomir

HY-R04514A

*rno-miR-543-3p agomir*	MicroRNA	Cancer
rno-miR-543-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-543-3p agomir rno-miR-543-3p agomir

HY-RI04514A

*rno-miR-543-3p antagomir*	MicroRNA	Cancer
rno-miR-543-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-543-3p antagomir rno-miR-543-3p antagomir

HY-D2947

CLIP-505	Fluorescent Dye	Others
CLIP-505 is a CLIP-tag specific dye substrate. CLIP-505 is excited using either the 488 or 543 laser line .

HY-173035

α-Glucosidase-IN-85	Glycosidase	Metabolic Disease
α-Glucosidase-IN-85 (Compound 8D1) is the inhibitor for α-Glucosidase with an IC₅₀ of 5.43 μM. α-Glucosidase-IN-85 can be used in research of type 2 diabetes .

HY-181510

CAII-IN-14	Carbonic Anhydrase	Others
CAII-IN-14 (Compound 3o) is a human carbonic anhydrase II (hCA II) inhibitor with a K_i value of 1.65 nM. CAII-IN-14 also inhibits hCA I(K_i = 6.15 nM) and hCA IX(K_i = 5.43 nM). CAII-IN-14 exhibits predicted drug-like properties .

HY-181166

EGFR-IN-194	EGFR Apoptosis	Cancer
EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC₅₀ of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia .

HY-159564

iNOS/COX-2-IN-3	COX NO Synthase	Inflammation/Immunology
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

Cat. No.	Product Name	Type