2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation PI3K/Akt/mTOR MAPK/ERK Pathway
  3. Keap1-Nrf2 Reactive Oxygen Species (ROS) PI3K Akt p38 MAPK
  4. SH543

SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor κB ligand (RANKL)-induced osteoclastogenesis with an IC50 of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research.

For research use only. We do not sell to patients.

SH543

SH543 Chemical Structure

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SH543 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

View All p38 MAPK Isoform Specific Products:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description

SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor κB ligand (RANKL)-induced osteoclastogenesis with an IC50 of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research[1].

Molecular Weight

543.82

Formula

C37H53NO2
SMILES

C[C@]12[C@]([H])(C(C)(C3=C(C2)C=C4C=CC=CC4=N3)C)CC[C@@]5([C@@]1(C[C@H]([C@]6([C@]5(CC[C@@H]6[C@@]7(CC[C@@H](O7)C(C)C)C)C)[H])O)[H])C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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SH543 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SH543SH 543SH-543Keap1-Nrf2Reactive Oxygen Species (ROS)PI3KAktp38 MAPKPhosphoinositide 3-kinasePKBProtein kinase BRANKL-induced osteoclastogenesisKEAP1Nrf2-HO-1 antioxidant pathwayPI3K-AKTMAPK signaling pathwayosteoporosisInhibitorinhibitorinhibit

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