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Cat. No.: HY-103336

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Tocrifluor 1117

Name: Tocrifluor 1117
Brand: MedChemExpress
SKU: HY-103336
Availability: PreOrder

(Synonyms: T1117)

Tocrifluor 1117 is a selective GPR55 ligand and fluorescent probe. Tocrifluor 1117 shows extremely low affinity for mouse CB1 receptors (K_i >1000 nM) and only weakly displaces CB1 agonists. Tocrifluor 1117 specifically activates GPR55 to trigger intracellular calcium oscillations, and binds to vascular smooth muscle, endothelial and adventitial cells; all these binding effects are inhibited by pretreatment with unlabeled AM251 or O1602. Tocrifluor 1117 can clearly visualize the distribution of GPR55 in vascular tissues via confocal microscopy, while its uptake in cancer cells is completely dependent on GPR55 expression.

For research use only. We do not sell to patients.

CAS No.: 1186195-59-4
Formula: C₅₆H₅₃Cl₂N₇O₅
Molecular Weight:974.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Tocrifluor 1117 Chemical Structure

CAS No.: 1186195-59-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

CB1

>1000 nM (Ki)

All Cannabinoid Receptor Isoforms :

In Vitro

Tocrifluor 1117 (1 μM; 60 min) exhibits low affinity for CB₁ receptors in wild-type mouse brain membranes, displacing only 10% of bound [³H]CP55940 at a concentration of 1 μM^[1].
Tocrifluor 1117 (0.3-3 μM) activates GPR55 receptors, inducing an oscillatory calcium response in GPR55-expressing HEK293 cells at 0.3 μM, with no response observed in control HEK293 cells lacking GPR55 even at 3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1186195-59-4
Molecular Weight 974.97
Formula C₅₆H₅₃Cl₂N₇O₅
SMILES

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C4=CC=C(CCCNC(C5=CC6=C(C7(C8=C(OC9=C7C=CC(N(C)C)=C9)C=C(N(C)C)C=C8)OC6=O)C=C5)=O)C=C4)C=C3)=C1C)NN%10CCCCC%10
Synonyms

T1117
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daly C J, Ross R A, Whyte J, et al. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid‐like’receptors in small arteries[J]. British journal of pharmacology, 2010, 159(4): 787-796.

[2]. Singh NS, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016;111:757-766. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Tocrifluor 1117

AM251

Oleamide

Rimonabant

Taranabant

O1918

MJ15

Otenabant

AM281

N-Arachidonylglycine

GW842166X

CB1 antagonist 2

Org 27569

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Tocrifluor 1117

AM251

Oleamide

Rimonabant

Taranabant

O1918

MJ15

Otenabant

AM281

N-Arachidonylglycine

GW842166X

CB1 antagonist 2

Org 27569

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Tocrifluor 1117 Related Classifications

HY-103336 Related Classifications

Bioz