Tocrifluor 1117
Tocrifluor 1117 is a selective GPR55 ligand and fluorescent probe. Tocrifluor 1117 shows extremely low affinity for mouse CB1 receptors (Ki >1000 nM) and only weakly displaces CB1 agonists. Tocrifluor 1117 specifically activates GPR55 to trigger intracellular calcium oscillations, and binds to vascular smooth muscle, endothelial and adventitial cells; all these binding effects are inhibited by pretreatment with unlabeled AM251 or O1602. Tocrifluor 1117 can clearly visualize the distribution of GPR55 in vascular tissues via confocal microscopy, while its uptake in cancer cells is completely dependent on GPR55 expression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1186195-59-4
- 分子式: C56H53Cl2N7O5
- 分子量:974.97
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-15443
AM251CB1 Receptor Antagonist -
HY-N2327
OleamideEndogenous Metabolite -
HY-14136
Rimonabant -
HY-10013
TaranabantCB1 Receptor Invert Agonist -
HY-103335
O1918 -
HY-103327
MJ15CB1 antagonist -
HY-10871
OtenabantCannabinoid Receptor Antagonist -
HY-13505
AM281CB1 Antagonist -
HY-103332
N-ArachidonylglycineGPR18 Agonist -
HY-14167
GW842166XCannabinoid Receptor Agonist -
HY-116649
CB1 antagonist 2CB1R Antagonist -
HY-13288
Org 27569Cannabinoid Receptor Modulator
生物活性
製品説明
IC50 & Target
[1]|
CB1 >1000 nM (Ki) |
体外実験
Tocrifluor 1117 (0.3-3 μM) activates GPR55 receptors, inducing an oscillatory calcium response in GPR55-expressing HEK293 cells at 0.3 μM, with no response observed in control HEK293 cells lacking GPR55 even at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1186195-59-4
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分子量 974.97
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分子式 C56H53Cl2N7O5
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SMILES
O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C4=CC=C(CCCNC(C5=CC6=C(C7(C8=C(OC9=C7C=CC(N(C)C)=C9)C=C(N(C)C)C=C8)OC6=O)C=C5)=O)C=C4)C=C3)=C1C)NN%10CCCCC%10
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別名
T1117
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tocrifluor 1117 関連分類
HY-103336 関連分類
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