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Results for "

DNA+and+RNA+synthesis

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

13

Natural
Products

4

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13704
    SN-38
    Maximum Cited Publications
    70 Publications Verification

    7-Ethyl-10-hydroxycamptothecin

    		 Drug Metabolite Topoisomerase ADC Payload Autophagy Infection Cancer
    SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
    SN-38
  • HY-13062
    Daunorubicin hydrochloride
    35+ Cited Publications

    Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

    		 Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic Infection Neurological Disease Cancer
    Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin hydrochloride
  • HY-13624A
    Epirubicin hydrochloride
    35+ Cited Publications

    4'-Epidoxorubicin hydrochloride

    		 DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic Infection Neurological Disease Inflammation/Immunology Cancer
    Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
    Epirubicin hydrochloride
  • HY-13062A
    Daunorubicin
    35+ Cited Publications

    Daunomycin; RP 13057; Rubidomycin

    		 Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis Infection Neurological Disease Cancer
    Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin
  • HY-13624
    Epirubicin
    35+ Cited Publications

    4'-Epidoxorubicin

    		 DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic Cancer
    Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
    Epirubicin
  • HY-B1907
    Rifamycin sodium
    2 Publications Verification

    Rifamycin SV sodium

    		 Antibiotic Bacterial DNA/RNA Synthesis Infection Inflammation/Immunology
    Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
    Rifamycin sodium
  • HY-13704S
    SN-38-d3

    NK012-d3

    		 Topoisomerase ADC Payload Autophagy Cancer
    SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively .
    SN-38-d3
  • HY-153013
    SN38-COOH

    		Drug-Linker Conjugates for ADC Cancer
    SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis .
    SN38-COOH
  • HY-13744
    Rubitecan

    RFS 2000; 9-Nitrocamptothecin

    		 Topoisomerase Cancer
    Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .
    Rubitecan
  • HY-17026E
    Gemcitabine triphosphate trisodium

    dFdCTP trisodium

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate trisodium
  • HY-N6961
    Lapachol
    3 Publications Verification

    		 Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
    Lapachol
  • HY-13704R
    SN-38 (Standard)

    7-Ethyl-10-hydroxycamptothecin (Standard)

    		 Drug Metabolite Reference Standards Topoisomerase ADC Payload Autophagy Cancer
    SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
    SN-38 (Standard)
  • HY-17026A
    Gemcitabine triphosphate

    dFdCTP

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate
  • HY-B1907A
    Rifamycin
    2 Publications Verification

    Rifamycin SV

    		 Antibiotic Bacterial DNA/RNA Synthesis Infection
    Rifamycin (Rifamycin SV) is an orally active ansamycin antibiotic. Rifamycin inhibits DNA-dependent RNA synthesis. Rifamycin has antibacterial activity against Mycobacterium tuberculosis. Rifamycin interferes with hepatic bile acid metabolism. Rifamycin has anti-inflammatory effects. Rifamycin can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
    Rifamycin
  • HY-138581
    DMT-dA(PAc) Phosphoramidite

    		Phosphoramidites DNA/RNA Synthesis Infection Cancer
    DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite and can be used for DNA or RNA synthesis.
    DMT-dA(PAc) Phosphoramidite
  • HY-B2067
    Cymoxanil

    		Environmental Pollutants Fungal DNA/RNA Synthesis Infection
    Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora .
    Cymoxanil
  • HY-105387
    Heliquinomycin

    		DNA/RNA Synthesis Bacterial Topoisomerase Infection Cancer
    Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .
    Heliquinomycin
  • HY-103396
    Trimetrexate glucuronate
    2 Publications Verification

    CI-898 glucuronate

    		 Antifolate Bacterial Infection Cancer
    Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .
    Trimetrexate glucuronate
  • HY-13624AR
    Epirubicin hydrochloride (Standard)

    4'-Epidoxorubicin hydrochloride (Standard)

    		 Reference Standards DNA/RNA Synthesis Topoisomerase Apoptosis Antibiotic Cancer
    Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
    Epirubicin hydrochloride (Standard)
  • HY-B2067S
    Cymoxanil-d3

    		Isotope-Labeled Compounds Fungal DNA/RNA Synthesis Infection
    Cymoxanil-d3 is the deuterium labeled Cymoxanil (HY-B2067). Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora .
    Cymoxanil-d3
  • HY-B2067R
    Cymoxanil (Standard)

    		Reference Standards Fungal DNA/RNA Synthesis Infection
    Cymoxanil (Standard) is the analytical standard of Cymoxanil (HY-B2067). This product is intended for research and analytical applications. Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.
    Cymoxanil (Standard)
  • HY-119182
    Mitonafide
    2 Publications Verification

    NSC 300288

    		 DNA/RNA Synthesis Cancer
    Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia .
    Mitonafide
  • HY-108876
    Daunorubicin citrate

    Daunomycincitrate; RP 13057citrate; Rubidomycincitrate

    		 Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis Infection Neurological Disease Cancer
    Daunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin citrate
  • HY-N6961R
    Lapachol (Standard)

    		Reference Standards Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
    Lapachol (Standard)
  • HY-W654130
    Daunorubicin-13C,d3

    Daunomycin-13C,d3; RP 13057-13C,d3; Rubidomycin-13C,d3

    		 Isotope-Labeled Compounds Bacterial ADC Payload Apoptosis Antibiotic Topoisomerase Autophagy DNA/RNA Synthesis Infection
    Daunorubicin- 13C,d3 is 13C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin-13C,d3
  • HY-13062R
    Daunorubicin hydrochloride (Standard)

    Daunomycin hydrochloride (Standard); RP 13057 hydrochloride (Standard); Rubidomycin hydrochloride (Standard)

    		 Reference Standards Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic Infection Neurological Disease Cancer
    Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin hydrochloride (Standard)
  • HY-122123
    S-6123

    		Bacterial Antibiotic Infection
    S-6123 is a potent antimicrobial compound of the oxazolidinone series. S-6123 inhibits ribosomal protein synthesis without inhibiting DNA or RNA synthesis .
    S-6123
  • HY-N13898
    Alldimycin A

    		DNA/RNA Synthesis Cancer
    Alldimycin A is an anthracycline compound that inhibits RNA and DNA syntheses. Alldimycin A inhibits the growth, DNA and RNA synthesis of murine leukemic L1210, with IC50 values of 0.05 μg/mL, 0.92 μg/mL, and 0.47 μg/mL, respectively .
    Alldimycin A
  • HY-124116
    PD 121373

    		DNA/RNA Synthesis Cancer
    PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the synthesis of DNA and RNA. The IC50 values of PD 121373 for inhibiting DNA and RNA synthesis in L1210 cells are 0.5 μM and 0.3 μM, respectively .
    PD 121373
  • HY-119182R
    Mitonafide (Standard)

    NSC 300288 (Standard)

    		 DNA/RNA Synthesis Reference Standards Cancer
    Mitonafide (Standard) is the analytical standard of Mitonafide. This product is intended for research and analytical applications. Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia .
    Mitonafide (Standard)
  • HY-103396R
    Trimetrexate glucuronate (Standard)

    CI-898 glucuronate (Standard)

    		 Reference Standards Antifolate Bacterial Infection Cancer
    Trimetrexate (glucuronate) (Standard) is the analytical standard of Trimetrexate (glucuronate). This product is intended for research and analytical applications. Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .
    Trimetrexate glucuronate (Standard)
  • HY-W844796
    2-Amino-5-methyl-5-hexenoic acid

    (S)-2-Amino-5-methylhex-5-enoic acid

    		 Bacterial Amino Acid Derivatives Infection
    2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12 . X
    2-Amino-5-methyl-5-hexenoic acid
  • HY-B1907R
    Rifamycin sodium (Standard)

    Rifamycin SV sodium (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Rifamycin (sodium) (Standard) is the analytical standard of Rifamycin (sodium). This product is intended for research and analytical applications. Rifamycin sodium (Rifamycin SV sodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
    Rifamycin sodium (Standard)
  • HY-182258
    Ulicyclamide

    		DNA/RNA Synthesis Cancer
    Ulicyclamide is a cytotoxic cyclic peptide found in the tunicate Lissoclinum patella.Ulicyclamide inhibits DNA and RNA synthesis in leukemia cells. Ulicyclamide can be used for the research of leukemia .
    Ulicyclamide
  • HY-106795
    502U83

    		DNA/RNA Synthesis Cancer
    502U83 is an anti-cancer agent. 502U83 can inhibit DNA and RNA synthesis (IC50 ≈ 30 µM). 502U83 can be used for research on cancers such as leukemia .
    502U83
  • HY-13062AS
    Daunorubicin-13C,d3 TFA

    Daunomycin-13C,d3 TFA); RP 13057-13C,d3 TFA; Rubidomycin-13C,d3 TFA

    		 Isotope-Labeled Compounds Antibiotic Apoptosis ADC Payload DNA/RNA Synthesis Autophagy Topoisomerase Bacterial Infection Neurological Disease Cancer
    Daunorubicin- 13C,d3 TFA (Daunomycin- 13C,d3 TFA) is the deuterium and 13C-labeled Daunorubicin TFA. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
    Daunorubicin-13C,d3 TFA

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