Heliquinomycin
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth.
For research use only. We do not sell to patients.
- CAS No.: 178182-49-5
- Formula: C33H30O17
- Molecular Weight:698.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Helicase |
Topoisomerase I |
Topoisomerase II |
Heliquinomycin (18 h) shows strong inhibitory activity against Gram-positive bacteria strains with MIC values of 0.1-0.39 μM[1].
Heliquinomycin inhibits the growth of HeLa S3, LI210 leukemia, IMC,carcinoma, B16 meranoma cells, with IC50s of 0-1.6 μg/mL[1].
Heliquinomycin (30 and 100 μg/mL) inhibits topoisomerase II and I enzymes activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 178182-49-5
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Molecular Weight 698.58
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Formula C33H30O17
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SMILES
OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O
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Initial Source
Streptomyces sp. MJ929-SF2.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [Content Brief]
[2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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