1. Cell Cycle/DNA Damage Anti-infection
  2. DNA/RNA Synthesis Bacterial Topoisomerase
  3. Heliquinomycin

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth.

For research use only. We do not sell to patients.

Heliquinomycin Chemical Structure

Heliquinomycin Chemical Structure

CAS No. : 178182-49-5

Size Price Stock Quantity
1 mg USD 1855 Get quote 2 weeks 1 week
5 mg   Get quote  
10 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].

IC50 & Target[2]

Topoisomerase I

 

Topoisomerase II

 

In Vitro

Heliquinomycin (18 h) shows strong inhibitory activity against Gram-positive bacteria strains with MIC values of 0.1-0.39 μM[1].
Heliquinomycin inhibits the growth of HeLa S3, LI210 leukemia, IMC,carcinoma, B16 meranoma cells, with IC50s of 0-1.6 μg/mL[1].
Heliquinomycin (30 and 100 μg/mL) inhibits topoisomerase II and I enzymes activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Heliquinomycin (100 mg/kg, i.p.) does not show any toxicity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

698.58

Formula

C33H30O17

CAS No.
SMILES

OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O

Initial Source

Streptomyces sp. MJ929-SF2.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Heliquinomycin
Cat. No.:
HY-105387
Quantity:
MCE Japan Authorized Agent: