178182-49-5
Chemical Structure
Heliquinomycin
- CAS No.: 178182-49-5
- Formula:C33H30O17
- Molecular Weight:698.58
IUPAC Name: methyl (2R,3R,3'R)-3',4,9,10'-tetrahydroxy-3-(((2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-5,8,9'-trioxo-4',5,8,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate
InChIKey: MLFZQFHGXSVTGX-MCTZXALVSA-N
SMILES: OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O
Biological Activity: Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].
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Heliquinomycin | Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth. | |||||||||||||||||||||
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References
- [1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [Content Brief]
- [2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6. [Content Brief]
