Ulicyclamide 

Ulicyclamide is a cytotoxic cyclic peptide found in the tunicate Lissoclinum patella.Ulicyclamide inhibits DNA and RNA synthesis in leukemia cells. Ulicyclamide can be used for the research of leukemia^[1].

Ulicyclamide (dose-response curve range; 48 h) is cytotoxic against cultured L1210 mouse leukemia cells in vitro, with an IC₅₀ of 13 μg/mL after 48 h of incubation^[1].
Ulicyclamide (dose-response curve range; 2 h) potently inhibits both DNA and RNA syntheses (IC₅₀ = 2.2 μg/mL for each) in cultured L1210 mouse leukemia cells after 2 hr of incubation, while having no effect on protein synthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

677.84

C₃₃H₃₉N₇O₅S₂

74839-81-9

O=C(N1CCC[C@]1(C2=N[C@]([H])3[C@H](O2)C)[H])[C@@H](NC(C4=CSC([C@H](NC(C5=CSC([C@@H](NC3=O)[C@@H](C)CC)=N5)=O)C)=N4)=O)CC6=CC=CC=C6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kohda K, et al. Ulicyclamide is cytotoxic against L1210 cells in vitro and inhibits both DNA and RNA syntheses. Biochem Pharmacol. 1989 Dec 15;38(24):4500-2.
   [Content Brief]