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Decarboxylases Inhibitors

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Peptides

6

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150637
    Mab Aspartate Decarboxylase-IN-1

    		Bacterial Infection
    Mab Aspartate Decarboxylase-IN-1 is a potent aspartate decarboxylase (PanD) inhibitor with an IC50 value of 56.3 µM. Mab Aspartate Decarboxylase-IN-1 shows antibacterial activity .
    Mab Aspartate Decarboxylase-IN-1
  • HY-N3394
    Lecanoric acid

    		Others Infection
    Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .
    Lecanoric acid
  • HY-133957
    Fluoromevalonate

    6-Fluoromevalonate; FMev

    		 Biochemical Assay Reagents Others
    6-Fluoromevalonate is a mevalonate-pyrophosphate decarboxylase inhibitor.
    Fluoromevalonate
  • HY-U00065
    Tritoqualine

    Inhibostamin; Hypostamine

    		 Others Inflammation/Immunology
    Tritoqualine is used as a histidine decarboxylase inhibitor.
    Tritoqualine
  • HY-13746
    Sardomozide

    CGP 48664; SAM-486A

    		 Others Cancer
    Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
    Sardomozide
  • HY-13746B
    Sardomozide dihydrochloride
    3 Publications Verification

    CGP 48664A

    		 Others Cancer
    Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
    Sardomozide dihydrochloride
  • HY-Y0367
    Maleic Acid
    1 Publications Verification
    Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
    Maleic Acid
  • HY-B0404A
    Benserazide hydrochloride
    3 Publications Verification

    Serazide; Ro 4-4602

    		 Others Neurological Disease
    Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC) .
    Benserazide hydrochloride
  • HY-N2553
    4-Deoxypyridoxine 5'-phosphate

    		LPL Receptor Metabolic Disease
    4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase .
    4-Deoxypyridoxine 5'-phosphate
  • HY-B0744
    Eflornithine
    Maximum Cited Publications
    10 Publications Verification

    DFMO; MDL71782; RMI71782; α-difluoromethylornithine

    		 Parasite Infection Cancer
    Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
    Eflornithine
  • HY-B0744A
    Eflornithine hydrochloride

    DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride

    		 Parasite Infection Cancer
    Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
    Eflornithine hydrochloride
  • HY-N0240
    Herbacetin
    4 Publications Verification

    		 Others Cancer
    Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .
    Herbacetin
  • HY-112619
    TES-991
    1 Publications Verification

    		 Others Metabolic Disease
    TES-991 is a potent and selective human α‑Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.
    TES-991
  • HY-W003445
    4-Bromo-3-hydroxybenzoic acid

    		Endogenous Metabolite Neurological Disease
    4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes .
    4-Bromo-3-hydroxybenzoic acid
  • HY-B0744B
    Eflornithine hydrochloride hydrate
    Maximum Cited Publications
    10 Publications Verification

    DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate

    		 Parasite Cancer
    Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .
    Eflornithine hydrochloride hydrate
  • HY-111365
    TES-1025
    3 Publications Verification

    		 Others Metabolic Disease
    TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM .
    TES-1025
  • HY-N0575
    Pinocembrin
    4 Publications Verification

    (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone

    		 Bacterial Reactive Oxygen Species Autophagy Infection Inflammation/Immunology Cancer
    Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .
    Pinocembrin
  • HY-B0404AS
    Benserazide-d3 hydrochloride

    Serazide-d3; Ro 4-4602-d3

    		 Isotope-Labeled Compounds Neurological Disease
    Benserazide-d3 (hydrochloride) is the deuterium labeled Benserazide hydrochloride. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC)[1].
    Benserazide-d3 hydrochloride
  • HY-Y0367S
    Maleic Acid-d2

    Maleic-2,3-d2 acid

    		 Bacterial Endogenous Metabolite Infection
    Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].
    Maleic Acid-d2
  • HY-W016349
    Chelidamic acid

    		Others Others
    Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
    Chelidamic acid
  • HY-B0311
    Carbidopa

    (S)-(-)-Carbidopa

    		 Aryl Hydrocarbon Receptor Neurological Disease Cancer
    Carbidopa ((S)-(-)-Carbidopa), a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
    Carbidopa
  • HY-B0311A
    Carbidopa monohydrate

    (S)-(-)-Carbidopa monohydrate
    Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .
    Carbidopa monohydrate
  • HY-125748
    CBM-301940

    		Others Cardiovascular Disease
    CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC50 value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases .
    CBM-301940
  • HY-B0404AR
    Benserazide hydrochloride (Standard)

    Serazide (Standard); Ro 4-4602 (Standard)

    		 Others Neurological Disease
    Benserazide (hydrochloride) (Standard) is the analytical standard of Benserazide (hydrochloride). This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC) .
    Benserazide hydrochloride (Standard)
  • HY-B0744C
    L-Eflornithine

    L-DFMO; L-RMI71782; L-α-difluoromethylornithine

    		 Parasite Cancer
    L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min -1 .
    L-Eflornithine
  • HY-W023493
    DL-Allylglycine

    2-Aminopent-4-enoic acid

    		 Amino Acid Derivatives Neurological Disease
    DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .
    DL-Allylglycine
  • HY-B0744D
    L-Eflornithine monohydrochloride

    L-DFMO monohydrochloride; ; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride

    		 Parasite Cancer
    L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min -1 .
    L-Eflornithine monohydrochloride
  • HY-B0311AS
    Carbidopa-d3 monohydrate

    (S)-(-)-Carbidopa-d3 (monohydrate)

    		 Aryl Hydrocarbon Receptor Neurological Disease Cancer
    Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
    Carbidopa-d3 monohydrate
  • HY-W041489
    Chelidonic acid
    1 Publications Verification

    		 NF-κB Caspase Inflammation/Immunology Cancer
    Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .
    Chelidonic acid
  • HY-100983
    Protein kinase inhibitor H-7 dihydrochloride

    		PKC Cancer
    Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .
    Protein kinase inhibitor H-7 dihydrochloride
  • HY-B0311S1
    Carbidopa-d3-1

    (S)-(-)-Carbidopa-d3

    		 Aryl Hydrocarbon Receptor Isotope-Labeled Compounds Neurological Disease
    Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
    Carbidopa-d3-1
  • HY-N3548
    Catalpalactone

    		NF-κB Inflammation/Immunology
    Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .
    Catalpalactone
  • HY-103355
    YM022
    1 Publications Verification

    		 CCR Metabolic Disease
    YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively . YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo .
    YM022
  • HY-106634
    Mitoguazone
    1 Publications Verification

    Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG

    		 HIV Apoptosis Infection Cancer
    Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .
    Mitoguazone
  • HY-B1537
    Azaribine

    2',3',5'-Tri-O-acetyl-6-azauridine
    Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research .
    Azaribine

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