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Results for "

Decarboxylases Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Decarboxylase (6) Malonyl-CoA Decarboxylase (1) Ornithine decarboxylase (ODC) (1) Amino Acid Derivatives (1) Apoptosis (3) Aryl Hydrocarbon Receptor (5) Autophagy (2) Bacterial (6) Biochemical Assay Reagents (1) Caspase (2) CCR (1) COMT (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (7) GABA Receptor (2) Glutathione S-transferase (1) HIV (2) Influenza Virus (1) Isotope-Labeled Compounds (2) LPL Receptor (1) NF-κB (3) Parasite (6) PKC (2) Reactive Oxygen Species (2) Reference Standards (1) Virus Protease (1) β-glucuronidase (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (1) Infection (12) Inflammation/Immunology (8) Metabolic Disease (8) Neurological Disease (14)

By Targets:

Amino Acid Decarboxylase (6)

Malonyl-CoA Decarboxylase (1)

Ornithine decarboxylase (ODC) (1)

Amino Acid Derivatives (1)

Apoptosis (3)

Aryl Hydrocarbon Receptor (5)

Autophagy (2)

Bacterial (6)

Biochemical Assay Reagents (1)

Caspase (2)

CCR (1)

COMT (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Endogenous Metabolite (7)

GABA Receptor (2)

Glutathione S-transferase (1)

HIV (2)

Influenza Virus (1)

Isotope-Labeled Compounds (2)

LPL Receptor (1)

NF-κB (3)

Parasite (6)

PKC (2)

Reactive Oxygen Species (2)

Reference Standards (1)

Virus Protease (1)

β-glucuronidase (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (1)

Infection (12)

Inflammation/Immunology (8)

Metabolic Disease (8)

Neurological Disease (14)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serpin Amino Acid Decarboxylase Ornithine decarboxylase (ODC) Malonyl-CoA Decarboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150637

Mab Aspartate Decarboxylase-IN-1	Bacterial	Infection
Mab Aspartate Decarboxylase-IN-1 is a potent *aspartate decarboxylase* (PanD)** inhibitor with an IC₅₀ value of 56.3 μM. Mab Aspartate Decarboxylase-IN-1 shows antibacterial activity .

HY-N3394

Lecanoric acid	Others	Infection
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-133957

Fluoromevalonate 6-Fluoromevalonate; FMev	Biochemical Assay Reagents	Others
6-Fluoromevalonate is a mevalonate-pyrophosphate decarboxylase inhibitor.

HY-13746B

Sardomozide dihydrochloride 5+ Cited Publications CGP 48664A	Others	Cancer
Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

HY-Y0367

Maleic Acid 1 Publications Verification	Endogenous Metabolite Bacterial	Infection
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-B0404A

Benserazide hydrochloride 5+ Cited Publications Serazide; Ro 4-4602	Others	Neurological Disease
Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC) .

HY-N2553

4-Deoxypyridoxine 5'-phosphate	LPL Receptor	Metabolic Disease
4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a K_i of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (K_i of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase .

HY-U00065

Tritoqualine Inhibostamin; Hypostamine	Amino Acid Decarboxylase	Inflammation/Immunology
Tritoqualine is a histidine decarboxylase inhibitor, that inhibits the release of histidine .

HY-13746

Sardomozide CGP 48664; SAM-486A	Others	Cancer
Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

HY-122968

Brocresine NSD-1065	Endogenous Metabolite	Neurological Disease
Brocresine (NSD-1065) is an orally active histidine decarboxylase inhibitor and inhibits the formation of histamine from histidine. Brocresine is also a L-amino acid decarboxylase inhibitor with both a peripheral and central action. Brocresine inhibits gastric secretory response to administration of exogenous gastrin .

HY-112619

TES-991 1 Publications Verification	Others	Metabolic Disease
TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC₅₀ of 3 nM.

HY-B0744

Eflornithine Maximum Cited Publications 12 Publications Verification DFMO; MDL71782; RMI71782; α-difluoromethylornithine	Parasite	Infection Cancer
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-B0744A

Eflornithine hydrochloride Maximum Cited Publications 12 Publications Verification DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride	Parasite	Infection Cancer
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-N0240

Herbacetin 4 Publications Verification	Ornithine decarboxylase (ODC)	Cancer
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an *Ornithine decarboxylase* (ODC)** allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Endogenous Metabolite	Neurological Disease
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a *histidine decarboxylase* (HDC)** inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC₅₀s of 1 mM for both enzymes .

HY-B0744B

Eflornithine hydrochloride hydrate Maximum Cited Publications 12 Publications Verification DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate	Parasite	Cancer
Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .

HY-111365

TES-1025 3 Publications Verification	Others	Metabolic Disease
TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC₅₀ of 13 nM .

HY-N0575

Pinocembrin 5 Publications Verification (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone	Bacterial Reactive Oxygen Species Autophagy	Infection Inflammation/Immunology Cancer
Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .

HY-B0404AS

Benserazide-d3 hydrochloride Serazide-d₃; Ro 4-4602-d₃	Isotope-Labeled Compounds	Neurological Disease
Benserazide-d₃ (hydrochloride) is the deuterium labeled Benserazide hydrochloride. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC) .

HY-Y0367S

Maleic Acid-d2 Maleic-2,3-d2 acid	Bacterial Endogenous Metabolite	Infection
Maleic Acid-d₂ is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

HY-N0240R

Herbacetin (Standard)	Others	Cancer
Herbacetin (Standard) is the analytical standard of Herbacetin. This product is intended for research and analytical applications. Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .

HY-W016349

Chelidamic acid	Amino Acid Decarboxylase	Others
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K_i of 33 μM.

HY-B0311A

Carbidopa monohydrate 1 Publications Verification (S)-(-)-Carbidopa monohydrate	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-B0311

Carbidopa 1 Publications Verification (S)-(-)-Carbidopa	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa), a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-B0404AR

Benserazide (hydrochloride) (Standard) Serazide (Standard); Ro 4-4602 (Standard)	Others	Neurological Disease
Benserazide (hydrochloride) (Standard) is the analytical standard of Benserazide (hydrochloride). This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC) .

HY-125748

CBM-301940	Malonyl-CoA Decarboxylase	Cardiovascular Disease
CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC₅₀ value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases .

HY-B0744C

L-Eflornithine L-DFMO; L-RMI71782; L-α-difluoromethylornithine	Parasite	Cancer
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a K_D of 1.3±0.3 µM, and a K_inact of 0.15±0.03 min ^-1 .

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-B0744D

L-Eflornithine monohydrochloride L-DFMO monohydrochloride; ; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride	Parasite	Cancer
L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a K_D of 1.3±0.3 µM, and a K_inact of 0.15±0.03 min ^-1 .

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Endogenous Metabolite Amino Acid Decarboxylase	Metabolic Disease Inflammation/Immunology
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-B0744BR

Eflornithine (hydrochloride hydrate) (Standard)	Parasite	Cancer
Eflornithine (hydrochloride hydrate) (Standard) is the analytical standard of Eflornithine (hydrochloride hydrate). This product is intended for research and analytical applications. Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .

HY-B0311AS

Carbidopa-d3 monohydrate (S)-(-)-Carbidopa-d₃ monohydrate	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-N0575R

Pinocembrin (Standard)	Bacterial Reactive Oxygen Species Autophagy	Infection Inflammation/Immunology Cancer
Pinocembrin (Standard) is the analytical standard of Pinocembrin. This product is intended for research and analytical applications. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-100983

Protein kinase inhibitor H-7 dihydrochloride	PKC	Cancer
Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

HY-W364575

Methyl-4-oxoretinoate	Drug Derivative	Cancer
Methyl-4-oxoretinoate is a derivative of Retinoic acid (HY-14649). Methyl-4-oxoretinoate inhibits TPA (HY-18739)-induced ornithine decarboxylase (ODC) activity, and carcinogen-induced papillomas in mouse skin .

HY-N2998R

Ganoderenic acid A (Standard)	β-glucuronidase	Metabolic Disease
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-B0311AR

Carbidopa (monohydrate) (Standard)	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-B0311S1

Carbidopa-d3-1 (S)-(-)-Carbidopa-d₃	Aryl Hydrocarbon Receptor Isotope-Labeled Compounds	Neurological Disease
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-N3548

Catalpalactone	NF-κB	Inflammation/Immunology
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-W016814R

(Z)-Aconitic acid (Standard)	Endogenous Metabolite	Others
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W041489R

Chelidonic acid (Standard)	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-103355

YM022 2 Publications Verification	CCR	Metabolic Disease
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the K_i values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively . YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo .

HY-W784565

5-Fluorouridine 5'-phosphate	DNA/RNA Synthesis	Cancer
5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a K_i value of 98 µM for human ODCase and a K_i value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research .

HY-W012264

3-O-Methyldopa monohydrate 1 Publications Verification 3-Methoxy-L-tyrosine monohydrate; 3-O-Methyl-L-DOPA monohydrate	COMT	Neurological Disease
3-O-Methyldopa monohydrate (3-Methoxy-L-tyrosine monohydrate) is a significant metabolite of L-DOPA produced through the action of catechol O-methyltransferase (COMT). Unlike its precursor, 3-O-Methyldopa does not serve as a substrate or inhibitor of L-amino acid decarboxylase activity. Additionally, the inhibition of COMT can amplify the anti-Parkinson effects of L-DOPA.

HY-115822

α-Fluoromethylhistidine dihydrochloride	Amino Acid Decarboxylase Glutathione S-transferase	Metabolic Disease
α-Fluoromethylhistidine dihydrochloride is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase, demonstrating significant potential in studying histidine metabolism and drug metabolism processes. α-Fluoromethylhistidine dihydrochloride offers an effective approach to inhibit enzymes involved in these metabolic pathways. α-Fluoromethylhistidine dihydrochloride has implications for drug development by revealing off-target effects that may influence physiological drug metabolism and elimination mechanisms.

HY-106634

Mitoguazone 2 Publications Verification Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG	HIV Apoptosis	Infection Cancer
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive *S-adenosyl-methionine decarboxylase* (SAMDC)** inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .

HY-100983R

Protein kinase inhibitor H-7 dihydrochloride (Standard)	Reference Standards PKC	Cancer
Protein kinase inhibitor H-7 (dihydrochloride) (Standard) is the analytical standard of Protein kinase inhibitor H-7 (dihydrochloride). This product is intended for research and analytical applications. Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

Cat. No.	Product Name	Target	Research Area

HY-134161

DL-α-(Difluoromethyl)arginine	Peptides	Metabolic Disease
DL-α-(Difluoromethyl)arginine is an potent, enzyme-activated and irreversible arginine decarboxylases inhibitor. DL-α-(Difluoromethyl)arginine blocks the arginine decarboxylase activity of E.coli and Pseudomonas aeruginosa in vivo .