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Sardomozide dihydrochloride (Synonyms: CGP 48664A)

Cat. No.: HY-13746B Purity: >99.0%
Handling Instructions

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

For research use only. We do not sell to patients.

Sardomozide dihydrochloride Chemical Structure

Sardomozide dihydrochloride Chemical Structure

CAS No. : 138794-73-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of Sardomozide dihydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

IC50 & Target

IC50: 5 nM (SAMDC)[1]

In Vitro

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].

References
Cell Assay
[2]

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

303.19

Formula

C₁₁H₁₆Cl₂N₆

CAS No.

138794-73-7

SMILES

N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N.[H]Cl.[H]Cl

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
Sardomozide dihydrochloride
Cat. No.:
HY-13746B
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Sardomozide dihydrochloride

Cat. No.: HY-13746B