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Sardomozide (Synonyms: CGP 48664; SAM-486A)

Cat. No.: HY-13746
Handling Instructions

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

For research use only. We do not sell to patients.

Sardomozide Chemical Structure

Sardomozide Chemical Structure

CAS No. : 149400-88-4

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Description

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

IC50 & Target

IC50: 5 nM (SAMDC)[1]

In Vitro

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

230.27

Formula

C₁₁H₁₄N₆

CAS No.

149400-88-4

SMILES

N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[2]

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

SardomozideCGP 48664 SAM-486ACGP48664CGP-48664OthersInhibitorinhibitorinhibit

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