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    Apoptosis
  2. HIV
    Apoptosis
  3. Mitoguazone

Mitoguazone (Synonyms: Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG)

Cat. No.: HY-106634 Purity: 99.38%
Handling Instructions

Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.

For research use only. We do not sell to patients.

Mitoguazone Chemical Structure

Mitoguazone Chemical Structure

CAS No. : 459-86-9

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 610 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment[1][2][3][4].

In Vitro

Mitoguazone competitively inhibits spermidine synthesis in lymphocytes at concentrations as low as 0.5 μg/mL. Levels of 30 μg/mL or more inhibit protein synthesis and mitochondrial respiration[1].
The ability of Mitoguazone to induce apoptosis by inhibiting the polyamine pathway is assessed in three Burkitt's lymphoma cell lines (Raji, Ramos and Daudi) and one prostate carcinoma cell line (MPC 3). Mitoguazone induces apoptosis in all the different human cancer cell lines tested in a concentration- and time-dependent way, and triggers a p53-independent programmed cell death in the human breast cancer MCF7 cell line[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in mice is investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reduced reflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stage the drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-free controls in contrast to an earlier stage of leukemia[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

184.20

Formula

C₅H₁₂N₈

CAS No.

459-86-9

SMILES

CC(/C=N/NC(N)=N)=N\NC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4289 mL 27.1444 mL 54.2888 mL
5 mM 1.0858 mL 5.4289 mL 10.8578 mL
10 mM 0.5429 mL 2.7144 mL 5.4289 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MitoguazoneMethylglyoxal-bis(guanylhydrazone) MGBG Methyl-GAGHIVApoptosisHuman immunodeficiency virusChemotherapeuticpolyaminebiosynthesisS-adenosyl-methioninedecarboxylasepolycarbonylcytotoxicmitochondrialantineoplasticInhibitorinhibitorinhibit

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Product Name:
Mitoguazone
Cat. No.:
HY-106634
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