2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Protein kinase inhibitor H-7 dihydrochloride

Protein kinase inhibitor H-7 dihydrochloride 

Cat. No.: HY-100983 Purity: 99.94%
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Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase).

For research use only. We do not sell to patients.

Protein kinase inhibitor H-7 dihydrochloride Chemical Structure

Protein kinase inhibitor H-7 dihydrochloride Chemical Structure

CAS No. : 108930-17-2

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Based on 1 publication(s) in Google Scholar

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Description

Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].

Molecular Weight

364.29

Formula

C14H19Cl2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (45.76 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7451 mL 13.7253 mL 27.4507 mL
5 mM 0.5490 mL 2.7451 mL 5.4901 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7451 mL 13.7253 mL 27.4507 mL 68.6266 mL
5 mM 0.5490 mL 2.7451 mL 5.4901 mL 13.7253 mL
10 mM 0.2745 mL 1.3725 mL 2.7451 mL 6.8627 mL
15 mM 0.1830 mL 0.9150 mL 1.8300 mL 4.5751 mL
20 mM 0.1373 mL 0.6863 mL 1.3725 mL 3.4313 mL
25 mM 0.1098 mL 0.5490 mL 1.0980 mL 2.7451 mL
30 mM 0.0915 mL 0.4575 mL 0.9150 mL 2.2876 mL
40 mM 0.0686 mL 0.3431 mL 0.6863 mL 1.7157 mL
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Protein kinase inhibitor H-7 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protein kinase inhibitor H-7108930-17-2Protein kinase inhibitor H7Protein kinase inhibitor H 7PKCProtein kinase Cprotein kinasephospholipaseornithine decarboxylaseODCskin tumourInhibitorinhibitorinhibit

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