Azaribine  (Synonyms: 2',3',5'-Tri-O-acetyl-6-azauridine)

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC₅₀=3.80 nM-1.73 μM against influenza A and B viruses; EC₅₀=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research^[1][2].

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 h) has cytotoxicity on MDCK cells (MTT: CC₅₀=19.66 μM)^[1].
Azaribine shows a potent inhibitory effect on BIRFLU multiplication (MDCK cells: EC₅₀=0.29 μM; A549 cells: EC₅₀=0.55 μM)^[1].
Azaribine shows against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells with EC₅₀ of 0.60 μM, 0.77 μM, 0.80 μM^[1].
Azaribine is against NC H1N1 during posttreatment in 16HBE cells (EC₅₀=1.58 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

371.30

C₁₄H₁₇N₃O₉

2169-64-4

Solid

White to off-white

CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)