2169-64-4
Chemical Structure
Azaribine
Synonym(s): 2',3',5'-Tri-O-acetyl-6-azauridine
- CAS No.: 2169-64-4
- Formula:C14H17N3O9
- Molecular Weight:371.30
IUPAC Name: (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)tetrahydrofuran-3,4-diyl diacetate
InChIKey: QQOBRRFOVWGIMD-OJAKKHQRSA-N
SMILES: CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O
Biological Activity: Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azaribine | 98.8% | Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research. | ||||||||||||||||||||
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References
- [1]. Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19. [Content Brief]
- [2]. Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12(9):1041. [Content Brief]
