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Farnesyl+Transferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Farnesyl Transferase (57) Akt (3) Antibiotic (1) Apoptosis (9) Autophagy (3) Bacterial (3) Caspase (2) Endogenous Metabolite (2) ERK (2) Fungal (1) GGTase (3) HCV (3) ICMT (1) Microtubule/Tubulin (1) mTOR (3) NOD-like Receptor (NLR) (1) p38 MAPK (1) Parasite (1) PI3K (2) Ras (14) Reference Standards (4) TGF-β Receptor (1) VEGFR (2) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (46) Cardiovascular Disease (2) Infection (13) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Targets Recommended: Farnesyl Transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15136

Lonafarnib Maximum Cited Publications 14 Publications Verification Sch66336	Farnesyl Transferase Ras Autophagy	Infection Neurological Disease Cancer
Lonafarnib (Sch66336) is a potent and orally active, and CNS-penetrant farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-10502

Tipifarnib Maximum Cited Publications 14 Publications Verification IND 58359; R115777	Farnesyl Transferase	Infection Cancer
Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC₅₀ of 0.86 nM. Antineoplastic activity and antiparasitic activity .

HY-15872A

FTI-277 hydrochloride 5+ Cited Publications	Farnesyl Transferase Apoptosis Ras	Infection Cancer
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

HY-16059

Arglabin (+)-Arglabin	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy	Inflammation/Immunology Cancer
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene .

HY-128350

FGTI-2734 1 Publications Verification	Farnesyl Transferase	Cancer
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

HY-100313A

YM-53601 5 Publications Verification	Farnesyl Transferase HCV	Infection Metabolic Disease
YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-16373

CP-609754 LNK-754; OSI-754	Farnesyl Transferase	Cancer
CP-609754 (LNK-754) is a potent and reversible *farnesyltransferase* inhibitor with potential anticancer activity.The IC₅₀ for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL . CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-128350A

FGTI-2734 mesylate 1 Publications Verification	Farnesyl Transferase γ-Glutamyl Transferase (GGT)	Cancer
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .

HY-16111

BMS-214662	Farnesyl Transferase Ras	Cancer
BMS-214662 is a *farnesyl transferase* inhibitor. BMS-214662 can effectively block the localization and function of Ras protein in the cell membrane by inhibiting the pro-group modification of Ras protein, thereby exerting anti-tumor activity. BMS-214662 has an IC₅₀ value of 1.3 nM for H-Ras and 8.4 nM for K-Ras. BMS-214662 can be used to study Ras-related tumor diseases .

HY-116514

(S)-(−)-Perillyl alcohol	Farnesyl Transferase Apoptosis Endogenous Metabolite	Cancer
(S)-(-)-Perillyl alcohol, a monoterpene, is an orally active *farnesyl transferase* and geranylgeranyl transferase inhibitor. (S)-(-)-Perillyl alcohol up-regulates the mannose-6-phosphate receptor, facilitating TGF-β1 activation and cytostasis,. (S)-(-)-Perillyl alcohol induces apoptosis in cancer cells, modulates cyclin D1 and AP-1 activity. (S)-(-)-Perillyl alcohol exhibits antitumor activity against sarcoma tumors in mice. (S)-(-)-Perillyl alcohol can be used for the research of squamous cell carcinoma of the esophagus and sarcoma 180 .

HY-15879

LB42708 1 Publications Verification	Farnesyl Transferase Apoptosis	Inflammation/Immunology
LB42708 is a potent, selective and orally active *farnesyltransferase* inhibitor. LB42708 inhibits farnesylation of H-Ras, N-Ras and K-Ras4B with IC₅₀s of 0.8 nM, 1.2 nM and 2.0 nM, respectively .

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-15873A

FTI 276 TFA	Farnesyl Transferase Ras p38 MAPK	Cancer
FTI 276 TFA is a farnesyltransferase (FTase) inhibitor with an IC₅₀ of 0.5 nM, and it exhibits selectivity for FTase over geranylgeranyltransferase I (GGTase I). FTI 276 TFA blocks the farnesylation of H-Ras and K-Ras4B, causes inactive Ras-Raf complexes to accumulate in the cytoplasm, and inhibits constitutive MAPK activation. FTI 276 TFA reduces the number, incidence and volume of tumors, and restricts the growth of tumors expressing activated K-ras. FTI 276 TFA can be used in research related to pulmonary adenoma .

HY-118563

Farnesylthioacetic acid	ICMT Apoptosis Ras	Cancer
Farnesylthioacetic acid is a competitive, non-substrate inhibitor of Prenylcysteine α-carboxyl methyltransferase. It acts as a non-substrate competitive inhibitor of Arabidopsis thaliana Prenylcysteine α-carboxyl methyltransferase and blocks methyltransferase activity. Farnesylthioacetic acid does not inhibit protein farnesyltransferase activity in Arabidopsis. It induces Apoptosis. Farnesylthioacetic acid regulates the subcellular localization of Ras protein, reducing the proportion of cytoplasmic Ras protein without disrupting membrane binding. It enhances ABA-induced seed dormancy, delays seed germination, and promotes maximum stomatal closure at lower exogenous ABA concentrations. Farnesylthioacetic acid can be used in studies related to promyelocytic leukemia .

HY-10502A

Tipifarnib (S enantiomer) IND-58359 S enantiomer; (S)-(-)-R-115777	Farnesyl Transferase	Cancer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC₅₀ of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

HY-16111A

BMS-214662 hydrochloride	Farnesyl Transferase Ras	Cancer
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC₅₀ value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras .

HY-15873

FTI 276	Farnesyl Transferase	Cancer
FTI-276 is a *protein farnesyl transferase* (PFT) inhibitor with IC₅₀*s of 0.9 and 0.5 nM for Plasmodium falciparum* and human.

HY-172423

Darlifarnib KO-2806	Farnesyl Transferase mTOR VEGFR	Cancer
Darlifarnib (KO-2806) is an orally active *farnesyl transferase* inhibitor. Darlifarnib inhibits the mTORC1 signaling pathway, thereby enhancing the anti-angiogenic properties of tyrosine kinase inhibitors. When used in combination with anti-VEGFR tyrosine kinase inhibitors, Darlifarnib promotes renal cell carcinoma tumor regression and inhibits tumor neovascularization. Darlifarnib sensitizes renal cell carcinoma tumors that progress after anti-VEGFR TKI treatment .

HY-12369

GGTI-2133 1 Publications Verification	GGTase	Inflammation/Immunology
GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma .

HY-15872

FTI-277	Farnesyl Transferase Ras ERK mTOR Caspase Apoptosis Akt PI3K Bacterial	Cardiovascular Disease Neurological Disease Cancer
FTI-277 is a farnesyltransferase (FTase) inhibitor. FTI-277 inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .

HY-110038

FTI-277 TFA	Farnesyl Transferase Ras ERK mTOR Apoptosis Caspase Akt PI3K Bacterial	Cardiovascular Disease Neurological Disease Cancer
FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .

HY-15136B

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Infection Cancer
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-119257

ABT-100 1 Publications Verification	Farnesyl Transferase Apoptosis	Cancer
ABT-100, a chemical probe, is a potent, highly selective and orally active *farnesyltransferase* inhibitor. ABT-100 inhibits cell proliferation (IC₅₀s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity .

HY-116428

L-744832	Farnesyl Transferase Ras TGF-β Receptor Apoptosis	Cancer
L-744832 is a farnesyl transferase inhibitor. L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras, but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis. L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .

HY-16013

A-228839	Farnesyl Transferase	Inflammation/Immunology
A-228839 is a potent *farnesyltransferase* inhibitor. A-228839 inhibits lymphocyte activation and cytokine production .

HY-116254

L-739750	Farnesyl Transferase	Others
L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC₅₀: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic .

HY-100313

YM-53601 free base	Farnesyl Transferase HCV	Metabolic Disease
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-12369A

GGTI-2133 TFA	GGTase	Inflammation/Immunology
GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma .

HY-16111A1

BMS-214662 mesylate	Farnesyl Transferase	Cancer
BMS-214662 mesylate is a potent and selective *farnesyl transferase* inhibitor with an IC₅₀ of 1.35 nM. BMS-214662 mesylate exhibits potent antitumor activity and can be utilized in cancer research .

HY-128044

Ftase inhibitor I B581	Farnesyl Transferase	Cancer
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras) .

HY-118916

FTI-2148	Farnesyl Transferase	Cancer
FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively .

HY-118916A

FTI-2148 diTFA	Farnesyl Transferase	Cancer
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and *farnesyl transferase* (FTase) with IC₅₀s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-128041

*alpha-Hydroxy farnesyl* phosphonic acid** Hydroxyfarnesyl phosphate	Farnesyl Transferase	Others
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.

HY-120044

L-739749	Farnesyl Transferase Ras	Cancer
L-739749 is a *farnesyl transferase* inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .

HY-125669

XR 3054	Farnesyl Transferase	Cancer
XR 3054 is an inhibitor for *Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC₅₀* of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC₅₀ of 8.8-21.4 μM .

HY-15136R

Lonafarnib (Standard) Sch66336 (Standard)	Reference Standards Farnesyl Transferase Ras Autophagy	Infection Cancer
Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

HY-142655

Ftase inhibitor III	Farnesyl Transferase	Infection
Ftase inhibitor III is an anion-dependent *Farnesyltransferase* inhibitor from a phenotypic screen.

HY-151566

Antifungal agent 46	Ras Farnesyl Transferase Fungal	Infection
Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein *farnesyltransferase* .

HY-U00327

Prenyl-IN-1	Farnesyl Transferase GGTase	Neurological Disease
Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.

HY-117807

A-176120	Ras Farnesyl Transferase VEGFR	Cancer
A-176120 is a selective inhibitor of *farnesyl transferase* (IC₅₀=1.2 nM) based on a farnesyl pyrophosphate (FPP) analog, with superior selectivity against GGTaseI (IC₅₀=423 nM), GGTaseII (IC₅₀=3000 nM), and SSase (IC₅₀>10 μM). A-176120 inhibits ras processing in H-ras transformed NIH3T3 cells and HCT116 K-ras mutant cells (ED₅₀=1.6 and 0.5 μM, respectively). A-176120 has antiangiogenic and antitumor activities in vivo and reduces capillary structure formation and VEGF secretion .

HY-129279

Andrastin A	Farnesyl Transferase	Cancer
Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species .

HY-10062

AZD3409 EBP-921	Akt Farnesyl Transferase	Cancer
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both *farnesyl transferase* and *geranylgeranyl transferase* I. AZD3409 inhibits the growth of breast cancer cells, with IC₅₀s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT** in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer .

HY-123242A

FTI-2153 TFA	Farnesyl Transferase	Cancer
FTI-2153 TFA is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 TFA is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-117893

BIM-46068	Farnesyl Transferase Ras	Cancer
BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC₅₀ = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer .

HY-N14820

Kurasoin A	Farnesyl Transferase	Others
Kurasoin A is a *farnesyltransferase* inhibitor .

HY-120614

BMS-186511	Farnesyl Transferase	Cancer
BMS-186511 is a farnesyltransferase (FT) inhibitor and shows anticancer activity .

HY-N9604

Andrastin C	Farnesyl Transferase	Cancer
Andrastin B is a protein *farnesyltransferase* inhibitor. Andrastin B has a common androstane skeleton .

HY-N13876

Andrastin D	Farnesyl Transferase	Cancer
Andrastin D is a protein *farnesyltransferase* inhibitor. Andrastin D has a common androstane skeleton .

Cat. No.	Product Name	Type

HY-118563

Farnesylthioacetic acid

Biochemical Assay Reagents

Farnesylthioacetic acid is a competitive, non-substrate inhibitor of Prenylcysteine α-carboxyl methyltransferase. It acts as a non-substrate competitive inhibitor of Arabidopsis thaliana Prenylcysteine α-carboxyl methyltransferase and blocks methyltransferase activity. Farnesylthioacetic acid does not inhibit protein farnesyltransferase activity in Arabidopsis. It induces Apoptosis. Farnesylthioacetic acid regulates the subcellular localization of Ras protein, reducing the proportion of cytoplasmic Ras protein without disrupting membrane binding. It enhances ABA-induced seed dormancy, delays seed germination, and promotes maximum stomatal closure at lower exogenous ABA concentrations. Farnesylthioacetic acid can be used in studies related to promyelocytic leukemia .

Species:	Human (3)
Tag:	His (2) Strep (1) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72193

	FDFT1 Protein, Human (His) DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; SQS; Squalene synthase; Squalene synthetase; SS	Human	E. coli
	FDFT1 is a key enzyme in cellular metabolism responsible for coordinating the condensation of two farnesyl pyrophosphate (FPP) molecules, a key step in sterol biosynthesis. The process proceeds in two distinct steps: First, two FPP molecules react to form the stable squalene diphosphate intermediate (PSQPP), releasing protons and inorganic diphosphate. FDFT1 Protein, Human (His) is the recombinant human-derived FDFT1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701885

	FNTA Protein, Human FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human is the recombinant human-derived FNTA protein, expressed by E. coli , with tag free.

HY-P701886

	FNTA Protein, Human (His, StrepⅡ) FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human (His, Strep) is the recombinant human-derived FNTA protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P83099

	FNTB Antibody (YA2844) FNTB; Protein farnesyltransferase subunit beta; FTase-beta; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta	WB, IP	Human
	FNTB Antibody (YA2844) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FNTB.

HY-P83099A

	FNTB Antibody (YA2844)(PBS only) FNTB; Protein farnesyltransferase subunit beta; FTase-beta; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta	WB, IP	Human
	FNTB Antibody (YA2844) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FNTB.

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HY-16373

CP-609754 LNK-754; OSI-754		Alkynes
CP-609754 (LNK-754) is a potent and reversible *farnesyltransferase* inhibitor with potential anticancer activity.The IC₅₀ for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL . CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Farnesyl+Transferase

Inhibitors & Agonists

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