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Cat. No.: HY-137139

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10'-Desmethoxystreptonigrin

10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC₅₀ of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg).

For research use only. We do not sell to patients.

CAS No.: 136803-89-9
Formula: C₂₄H₂₀N₄O₇
Molecular Weight:476.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

10'-Desmethoxystreptonigrin Chemical Structure

CAS No.: 136803-89-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 21 μM (Ras Farnesyltransferase)

All Antibiotic Isoforms :

Chemical Information

CAS No. 136803-89-9
Molecular Weight 476.44
Formula C₂₄H₂₀N₄O₇
SMILES

NC(C(C(C=CC=C1OC)=C1O)=C2C)=C(C3=CC=C(C4=O)C(C(C(N)=C4OC)=O)=N3)N=C2C(O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces albus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu WC, et al. 10'-Desmethoxystreptonigrin, a novel analog of streptonigrin. J Antibiot (Tokyo). 1992 Apr;45(4):454-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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10'-Desmethoxystreptonigrin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

10'-Desmethoxystreptonigrin Related Classifications

HY-137139 Related Classifications