10'-Desmethoxystreptonigrin, a novel analog of streptonigrin

  • J Antibiot (Tokyo). 1992 Apr;45(4):454-7. doi: 10.7164/antibiotics.45.454.
W C Liu  1 ,  M Barbacid ,  M Bulgar ,  J M Clark ,  A R Crosswell ,  L Dean ,  T W Doyle ,  P B Fernandes ,  S Huang ,  V Manne
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
PMID: 1592677 DOI: 10.7164/antibiotics.45.454
Abstract

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of Ras p21 protein. The compound was isolated from the fermentation broth and its structure determined. It is markedly cytotoxic to several human tumor cell lines and also exhibits potent broad-spectrum Antibacterial activity.

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