136803-89-9
Chemical Structure
10'-Desmethoxystreptonigrin
- CAS No.: 136803-89-9
- Formula:C24H20N4O7
- Molecular Weight:476.44
IUPAC Name: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3-methoxyphenyl)-3-methylpicolinic acid
InChIKey: ULSNCNUVHUNMCF-UHFFFAOYSA-N
SMILES: NC(C(C(C=CC=C1OC)=C1O)=C2C)=C(C3=CC=C(C4=O)C(C(C(N)=C4OC)=O)=N3)N=C2C(O)=O
Biological Activity: 10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg)[1].
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10'-Desmethoxystreptonigrin | 10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg). | |||||||||||||||||||||
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