L-739750
L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic.
For research use only. We do not sell to patients.
- CAS No.: 160141-08-2
- Formula: C23H39N3O6S2
- Molecular Weight:517.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 160141-08-2
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Molecular Weight 517.70
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Formula C23H39N3O6S2
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SMILES
O=C([C@H](CCS(=O)(C)=O)NC([C@H](CC1=CC=CC=C1)OC[C@H]([C@H](CC)C)NC[C@H](CS)N)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. 1. Kohl NE, et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5. [Content Brief]
[2]. Koblan KS, et al. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 1995 Apr;4(4):681-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-739750 Related Classifications
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