160141-08-2
Chemical Structure
L-739750
- CAS No.: 160141-08-2
- Formula:C23H39N3O6S2
- Molecular Weight:517.70
IUPAC Name: (S)-2-((S)-2-(((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoic acid
InChIKey: SIEXHGZWGJLLAC-OSTWSGHESA-N
SMILES: O=C([C@H](CCS(=O)(C)=O)NC([C@H](CC1=CC=CC=C1)OC[C@H]([C@H](CC)C)NC[C@H](CS)N)=O)O
Biological Activity: L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic[1][2].
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L-739750 | L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic. | |||||||||||||||||||||
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- [1]. 1. Kohl NE, et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5. [Content Brief]
- [2]. Koblan KS, et al. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 1995 Apr;4(4):681-8. [Content Brief]
Keywords
