Tubulin polymerization-IN-25
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .
For research use only. We do not sell to patients.
- CAS No.: 2490538-46-8
- Formula: C24H18N2O3S
- Molecular Weight:414.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.11 μM (Tubulin); 0.39 μM (FTase)[1]
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-435 | GI50 |
19 nM
Compound: 74
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Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
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[PMID: 34101463] |
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor (MTI-FTI hybrids) acting on tubulin polymerization and on FTase[1].
Tubulin polymerization-IN-25 (10 μM, 48 h) inhibits cells growth and induces cell cytotoxicity on multiple cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leukemia cells: SR, CCRF-CEM, K-562; lung cancer cell CCRF-CEMNCI-H522; melanoma cell M14
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Inhibited cell growth.
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Cell Line:NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer)
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Induced cell cytotoxicity.
Chemical Information
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CAS No. 2490538-46-8
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Molecular Weight 414.48
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Formula C24H18N2O3S
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SMILES
CC(C1=CC(C(C2=CC=C3NC4=C(C=CC=C4)SC3=C2)=O)=C5C=C(OC)C=CN15)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-25 Related Classifications
HY-149016 Related Classifications
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