Pepticinnamin E
Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research.
For research use only. We do not sell to patients.
- CAS No.: 147317-36-0
- Formula: C49H54ClN5O10
- Molecular Weight:908.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 42 µM (Farnesyltransferase)[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
>10 μM
Compound: 1
|
Cytotoxicity against drug resistant human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against drug resistant human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
| LNCaP | IC50 |
>10 μM
Compound: 1
|
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
| LNCaP C4-2B | IC50 |
>10 μM
Compound: 1
|
Cytotoxicity against drug resistant human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against drug resistant human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
| LNCaP C4-2B | IC50 |
>10 μM
Compound: 1
|
Cytotoxicity against human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
Chemical Information
-
CAS No. 147317-36-0
-
Molecular Weight 908.43
-
Formula C49H54ClN5O10
-
SMILES
O=C([C@@H](N(C)C([C@@H](N(C([C@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)CC2=CC=C(C=C2)O)=O)C)CC3=CC=C(C(O)=C3Cl)OC)=O)CC4=CC=CC=C4)OC[C@@H](N5)C(NCC5=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hinterding K, et al. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angew Chem Int Ed Engl. 1998 May 18;37(9):1236-1239. [Content Brief]
[2]. Santa Maria KC, et al. Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Chembiochem. 2019 Jun 3;20(11):1387-1393. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pepticinnamin E Related Classifications
HY-124205 Related Classifications
Powered by Bioz