147317-36-0
Chemical Structure
Pepticinnamin E
- CAS No.: 147317-36-0
- Formula:C49H54ClN5O10
- Molecular Weight:908.43
IUPAC Name: ((R)-3,6-dioxopiperazin-2-yl)methyl N-((S)-3-(2-chloro-3-hydroxy-4-methoxyphenyl)-2-((R)-3-(4-hydroxyphenyl)-N-methyl-2-((E)-3-(2-((Z)-pent-1-en-1-yl)phenyl)acrylamido)propanamido)propanoyl)-N-methyl-L-phenylalaninate
InChIKey: FAVCPKLIWNVVMG-AGJVLQOFSA-N
SMILES: O=C([C@@H](N(C)C([C@@H](N(C([C@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)CC2=CC=C(C=C2)O)=O)C)CC3=CC=C(C(O)=C3Cl)OC)=O)CC4=CC=CC=C4)OC[C@@H](N5)C(NCC5=O)=O
Biological Activity: Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research[1][2].
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Pepticinnamin E | Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research. | |||||||||||||||||||||
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- [1]. Hinterding K, et al. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angew Chem Int Ed Engl. 1998 May 18;37(9):1236-1239. [Content Brief]
- [2]. Santa Maria KC, et al. Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Chembiochem. 2019 Jun 3;20(11):1387-1393. [Content Brief]
Keywords
