1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. ABT-100

ABT-100 

Cat. No.: HY-119257
Handling Instructions

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.

For research use only. We do not sell to patients.

ABT-100 Chemical Structure

ABT-100 Chemical Structure

CAS No. : 450839-40-4

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Description

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity[1].

IC50 & Target

Farnesyltransferase[1]

In Vitro

ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth[1].

Cell Proliferation Assay[1]

Cell Line: EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
Concentration: 0.1-100 nM
Incubation Time: 7 days
Result: Demonstrated dose-dependent growth inhibition of human cancer cell lines.
In Vivo

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice[1].

Animal Model: C.B-17 scid male mice with EJ-1 cells[1]
Dosage: 6.25 mg/kg/day, 12.5 mg/kg/day
Administration: Subcutaneous injection; daily; for 21 days
Result: Regressed EJ-1 tumors in C.B-17 scid male mice.
Molecular Weight

504.46

Formula

C₂₇H₁₉F₃N₄O₃

CAS No.

450839-40-4

SMILES

N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[[email protected]](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ABT-100ABT100ABT 100Farnesyl TransferaseFtaseAntitumorfarnesyltransferaseantiproliferationregressesapoptosisangiogenesisorallyInhibitorinhibitorinhibit

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ABT-100
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HY-119257
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