450839-40-4
Chemical Structure
ABT-100
- CAS. Nr.: 450839-40-4
- Formula:C27H19F3N4O3
- Molecular Weight:504.46
IUPAC Name: (S)-6-(2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbonitrile
InChIKey: HEUVRFNVTLGKMZ-SANMLTNESA-N
SMILES: N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[C@](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1
Biological Activity: ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ABT-100 | 95.12% | ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.49
HY-146019HIV-1 inhibitor-24 -
Similarity Score 0.49
HY-146019AHIV-1 inhibitor-25 -
Similarity Score 0.47
HY-175675P2Y1 antagonist 4 -
Similarity Score 0.47
HY-15253Tiplaxtinin -
Similarity Score 0.47
HY-163483ELQ-598 -
Similarity Score 0.47
HY-16373CP-609754 -
Similarity Score 0.47
HY-U00401(Rac)-CP-609754 -
Similarity Score 0.45
HY-117948ML399 -
Similarity Score 0.45
HY-117948A(S)-ML399 -
Explore the MedChemAI to find more analogs
