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Referencia número: HY-146019A

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HIV-1 inhibitor-25

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC₅₀ value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC₅₀ of 13.6 nM, and exhibits relatively low cytotoxicity with a CC₅₀ of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC₅₀ of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.

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No. CAS: 2475658-74-1
Fòrmula: C₂₆H₁₉N₅O₂
Peso molecular:433.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HIV-1 inhibitor-25 Chemical Structure

No. CAS: 2475658-74-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

HIV (IIIB)

13.6 nM (EC₅₀)

HIV-1 (L100I)

1.2458 ± 0 μM (EC₅₀)

HIV-1 (K103N)

0.4383 ± 0 μM (EC₅₀)

HIV-1 (Y181C)

0.5075 ± 0 μM (EC₅₀)

HIV-1 (Y188L)

5.8136 ± 2 μM (EC₅₀)

HIV-1 (E138K)

0.1961 ± 0 μM (EC₅₀)

HIV-1 (F227L+V106A)

3.0683 ± 0 μM (EC₅₀)

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	33.13 μM Compound: (R)-12a	Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay	[PMID: 32712537]

Chemical Information

No. CAS 2475658-74-1
Peso molecular 433.46
Fòrmula C₂₆H₁₉N₅O₂
SMILES

N#CC1=CC=C(C2=CC=C([C@H](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen X, et al. Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2020;202:112549. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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HIV-1 inhibitor-25

Ver todos los productos específicos de isoformas HIV

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

HIV-1 inhibitor-25 Related Classifications

HY-146019A Related Classifications