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  2. HIV
  3. HIV-1 inhibitor-25

HIV-1 inhibitor-25 

Cat. No.: HY-146019A
Handling Instructions

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.

For research use only. We do not sell to patients.

HIV-1 inhibitor-25 Chemical Structure

HIV-1 inhibitor-25 Chemical Structure

CAS No. : 2475658-74-1

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Description

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1].

IC50 & Target[1]

HIV (IIIB)

13.6 nM (EC50)

HIV-1 (L100I)

1.2458 ± 0 μM (EC50)

HIV-1 (K103N)

0.4383 ± 0 μM (EC50)

HIV-1 (Y181C)

0.5075 ± 0 μM (EC50)

HIV-1 (Y188L)

5.8136 ± 2 μM (EC50)

HIV-1 (E138K)

0.1961 ± 0 μM (EC50)

HIV-1 (F227L+V106A)

3.0683 ± 0 μM (EC50)

Molecular Weight

433.46

Formula

C26H19N5O2

CAS No.
SMILES

N#CC1=CC=C(C2=CC=C([[email protected]](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HIV-1 inhibitor-25
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HY-146019A
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