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Cat. No.: HY-146019A

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HIV-1 inhibitor-25

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC₅₀ value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC₅₀ of 13.6 nM, and exhibits relatively low cytotoxicity with a CC₅₀ of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC₅₀ of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.

For research use only. We do not sell to patients.

CAS No.: 2475658-74-1
Formula: C₂₆H₁₉N₅O₂
Molecular Weight:433.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HIV-1 inhibitor-25 Chemical Structure

CAS No.: 2475658-74-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV (IIIB)

13.6 nM (EC₅₀)

HIV-1 (L100I)

1.2458 ± 0 μM (EC₅₀)

HIV-1 (K103N)

0.4383 ± 0 μM (EC₅₀)

HIV-1 (Y181C)

0.5075 ± 0 μM (EC₅₀)

HIV-1 (Y188L)

5.8136 ± 2 μM (EC₅₀)

HIV-1 (E138K)

0.1961 ± 0 μM (EC₅₀)

HIV-1 (F227L+V106A)

3.0683 ± 0 μM (EC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	33.13 μM Compound: (R)-12a	Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay	[PMID: 32712537]

Chemical Information

CAS No. 2475658-74-1
Molecular Weight 433.46
Formula C₂₆H₁₉N₅O₂
SMILES

N#CC1=CC=C(C2=CC=C([C@H](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2020;202:112549. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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HIV-1 inhibitor-25

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HIV-1 inhibitor-25 Related Classifications

HY-146019A Related Classifications