Tipifarnib (S enantiomer) (Synonyms: IND-58359 S enantiomer; (S)-(-)-R-115777)

Cat. No.: HY-10502A: FAQs
Data Sheet SDS COA Handling Instructions

Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC₅₀ of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

For research use only. We do not sell to patients.

Tipifarnib (S enantiomer) Chemical Structure

CAS No. : 192185-71-0

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 259	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 259	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 383	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1030	Get quote	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of Tipifarnib (S enantiomer):

Tipifarnib In-stock

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Description

Molecular Weight

489.40

Appearance

Solid

Formula

C₂₇H₂₂Cl₂N₄O

CAS No.

192185-71-0

SMILES

O=C1N(C)C2=C(C=C([[email protected]](C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (51.08 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0433 mL	10.2166 mL	20.4332 mL
5 mM	0.4087 mL	2.0433 mL	4.0866 mL
10 mM	0.2043 mL	1.0217 mL	2.0433 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) LCMS (289 KB)

Handling Instructions (2659 KB)

References

[1]. Kraus JM, et al. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem. 2009 Mar 26;52(6):1639-47. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Tipifarnib (S enantiomer)192185-71-0IND-58359 S enantiomer (S)-(-)-R-115777Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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