1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. Tipifarnib (S enantiomer)

Tipifarnib (S enantiomer) (Synonyms: IND-58359 S enantiomer; (S)-(-)-R-115777)

Cat. No.: HY-10502A Purity: 99.82%
Handling Instructions

Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

For research use only. We do not sell to patients.

Tipifarnib (S enantiomer) Chemical Structure

Tipifarnib (S enantiomer) Chemical Structure

CAS No. : 192185-71-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 235 In-stock
Estimated Time of Arrival: December 31
5 mg USD 214 In-stock
Estimated Time of Arrival: December 31
10 mg USD 348 In-stock
Estimated Time of Arrival: December 31
50 mg USD 936 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

Molecular Weight

489.40

Formula

C₂₇H₂₂Cl₂N₄O

CAS No.

192185-71-0

SMILES

O=C1N(C)C2=C(C=C([[email protected]](C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0433 mL 10.2166 mL 20.4332 mL
5 mM 0.4087 mL 2.0433 mL 4.0866 mL
10 mM 0.2043 mL 1.0217 mL 2.0433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tipifarnib (S enantiomer)IND-58359 S enantiomer (S)-(-)-R-115777Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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Product Name:
Tipifarnib (S enantiomer)
Cat. No.:
HY-10502A
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