1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase

L-778123 hydrochloride (Synonyms: L-778,123 hydrochloride)

Cat. No.: HY-16273A Purity: 99.64%
Handling Instructions

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.

For research use only. We do not sell to patients.

L-778123 hydrochloride Chemical Structure

L-778123 hydrochloride Chemical Structure

CAS No. : 253863-00-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 490 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. IC50 value: 2 nM [1] Target: FPTase in vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2] in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylated Rap1A in PBMCs. [1]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (56.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2607 mL 11.3035 mL 22.6070 mL
5 mM 0.4521 mL 2.2607 mL 4.5214 mL
10 mM 0.2261 mL 1.1304 mL 2.2607 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

442.34

Formula

C₂₂H₂₁Cl₂N₅O

CAS No.

253863-00-2

SMILES

N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
L-778123 hydrochloride
Cat. No.:
HY-16273A
Quantity:

L-778123 hydrochloride

Cat. No.: HY-16273A