2. Metabolic Enzyme/Protease
  3. Farnesyl Transferase
  4. L-778123 hydrochloride

L-778123 hydrochloride  (Synonyms: L-778,123 hydrochloride)

Cat. No.: HY-16273A Purity: 98.96%
COA Handling Instructions

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.

For research use only. We do not sell to patients.

L-778123 hydrochloride Chemical Structure

L-778123 hydrochloride Chemical Structure

CAS No. : 253863-00-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 85 In-stock
Solid
5 mg USD 77 In-stock
10 mg USD 110 In-stock
50 mg USD 319 In-stock
100 mg USD 539 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. IC50 value: 2 nM [1] Target: FPTase in vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2] in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylated Rap1A in PBMCs. [1]

Clinical Trial
Molecular Weight

442.34

Appearance

Solid

Formula

C22H21Cl2N5O
CAS No.
SMILES

N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (56.52 mM)

H2O : 25 mg/mL (56.52 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2607 mL 11.3035 mL 22.6070 mL
5 mM 0.4521 mL 2.2607 mL 4.5214 mL
10 mM 0.2261 mL 1.1304 mL 2.2607 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (45.21 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (5.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (5.09 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (5.09 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.96%

COA (257 KB) HNMR (262 KB) LCMS (108 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

L-778123253863-00-2L-778,123L778123L 778123Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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L-778123 hydrochloride
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