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L-778123 dihydrochloride

6 Cited Publications
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Based on 6 publication(s) in Google Scholar

L-778123 dihydrochloride is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM, respectively.

For research use only. We do not sell to patients.

  • CAS No.: 183499-56-1
  • Formula: C22H22Cl3N5O
  • Molecular Weight:478.80
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • L-778123 dihydrochloride Chemical Structure
    L-778123 dihydrochloride Chemical Structure
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
  • Experimental Validation Results for L-778123 dihydrochloride
CAS No.: 183499-56-1
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  • L-778123 dihydrochloride Chemical Structure
    L-778123 dihydrochloride Chemical Structure
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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jun 5. [Abstract]

    Customer Validation
     HMGCS1-overexpressed A549-CD19 cells were pre-treated with or without 10 μM L778123 (L-778123) for 12 h before cocultured with CD19 CAR-T for 24 h. The L778123 treatment did not diminish the enhanced resistance to lymphocyte killing conferred by HMGCS1 overexpression.

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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Aug 12;19(31):28644-28659. [Abstract]

    Customer Validation
     Representative MitoSOX-Red and JC-1 staining of IL-1β chondrocytes cocultured with CeO2-MSCsM-sec in the presence of L-778123 (10 μM; 16 h). When TNT formation was inhibited using L-778123, CeO2-MSCsM-sec failed to effectively alleviate mitochondrial ROS levels of damaged chondrocytes.

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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Aug 12;19(31):28644-28659. [Abstract]

    Customer Validation
     Quantification of intracellular ATP and ROS levels in IL-1β chondrocytes cocultured with CeO2-MSCsM-sec in the presence of L-778123 (10 μM; 16 h). adding L-778123 during the coculture process remarkably reduced the therapeutic effect of CeO2-MSCsM-sec, indicating the important role of TNTs as transport channels in the treatment process.

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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Aug 12;19(31):28644-28659. [Abstract]

    Customer Validation
     Flow cytometry analysis showing the transfer of MitoTracker Green-labeled mitochondria and FITC-labeled CeO2 from CM-Dil-labeled MSCsM-sec to the cells isolated from the joint cavity. L-778123 (80 mg/kg; i.p.; single administration 3 days before cell injection) reduced the transfer of mitochondria and CeO2 to joint-cavity cells.

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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Aug 12;19(31):28644-28659. [Abstract]

    Customer Validation
     Safranin-O staining of knee-joint sections at week 8 in DMM osteoarthritis mice receiving CeO2-MSCsM-sec with L-778123 (80 mg/kg; i.p.; twice weekly for 4 weeks). Following TNT inhibition with L-778123, surface abrasion and disorganized chondrocytes remained, indicating reduced cartilage protection by CeO2-MSCsM-sec.

  • 1/16

    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: Immunity. 2024 May 14;57(5):1056-1070.e5. [Abstract]

    Customer Validation
     Confocal images of CFSE-labeled iIEMCs and CMT-93 cells cocultured in the presence of DMSO or 10 μM L-778123 and after 24 h, immunolabeled with DAPI, E-cadherin, and Mcpt1.

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    L-778123 dihydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Feb 8:2023.02.07.527548. [Abstract]

    Customer Validation
     Western blot detection of specific protein markers in samples after tandem enrichment. GW4869 and L778123 (10 μM 12 h) are small-molecule inhibitors of exosome biogenesis and tunneling nanotube formation, respectively.

  • L-778123 dihydrochloride