2. Metabolic Enzyme/Protease MAPK/ERK Pathway GPCR/G Protein
  3. Farnesyl Transferase Ras
  4. BIM-46068

BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC50 = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer.

For research use only. We do not sell to patients.

BIM-46068

BIM-46068 Chemical Structure

CAS No. : 201487-53-8

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BIM-46068 Related Antibodies

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K-Ras H-Ras N-Ras Ras

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Description

BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC50 = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer[1].

In Vitro

BIM-46068 (0.1-10 µM, 48 h) specifically inhibits the processing of Ras in MiaPaCa-2 cancer cells[1].
BIM-46068 (96 h) inhibits the growth of cells bearing the wild-type ras as well as cells with the different mutated ras (K-ras, N-ras, or H-ras) and effectively inhibits the multidrug-resistant cell line T24R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIM-46068 Related Antibodies

Western Blot Analysis[1]

Cell Line: MiaPaCa-2 cells
Concentration: 0.1 µM, 1 µM, 10 µM
Incubation Time: 48 h
Result: Caused a change in the electrophoretic migration rate of H-Ras protein in MiaPaCa-2 cells, from rapid migration (farnesylated form) to slow migration (unfarnesylated form).
In Vivo

BIM-46068 (1-30 mg/kg, i.p., once daily for 10 days) significantly reduces tumor growth in a dose-dependent manner, and no signs of toxicity, such as weight loss or death, are observed at the highest dose (30 mg/kg)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice were implanted s.c. with MiaPaCa-2 cells (5 × 106), a human pancreatic tumor cell line expressing mutated K-ras[1].
Dosage: 1 mg/kg, 10 mg/kg, 30 mg/kg
Administration: I.p., once daily for 10 days
Result: Significantly reduced tumor growth in a dose-dependent manner.
On day 34 post-implantation, the mean tumor volume in the 30 mg/kg group was reduced by 50% compared to the control group.
Molecular Weight

494.78

Formula

C21H42N4O3S3
CAS No.
SMILES

CSCC[C@@H](C(OC)=O)NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIM-46068 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIM-46068201487-53-8BIM46068BIM 46068Farnesyl TransferaseRasFtaseFarnesyltransferaseFTaseRas proteinH-RasK-RasN-RasInhibitorinhibitorinhibit

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