Search Result

Results for "

Mouse Peritoneal Macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Bacterial (1) COX (1) DAGL (1) Drug Derivative (1) ERK (2) Histamine Receptor (1) IKK (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JNK (1) Leukotriene Receptor (1) Lipoxygenase (1) MAGL (1) Microtubule/Tubulin (1) NF-κB (2) NOD-like Receptor (NLR) (3) p38 MAPK (2) Parasite (1) Phosphodiesterase (PDE) (3) Platelet-activating Factor Receptor (PAFR) (1) TNF Receptor (3) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (16) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Adenosine Receptor (2)

Bacterial (1)

COX (1)

DAGL (1)

Drug Derivative (1)

ERK (2)

Histamine Receptor (1)

IKK (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

JNK (1)

Leukotriene Receptor (1)

Lipoxygenase (1)

MAGL (1)

Microtubule/Tubulin (1)

NF-κB (2)

NOD-like Receptor (NLR) (3)

p38 MAPK (2)

Parasite (1)

Phosphodiesterase (PDE) (3)

Platelet-activating Factor Receptor (PAFR) (1)

TNF Receptor (3)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (16)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-18540

KT109 1 Publications Verification	MAGL DAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .

HY-112825

TSI-01	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC₅₀s=0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). 60 μM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

HY-NP070

Lotus tetragonolobus lectin LTL		Inflammation/Immunology
Lotus tetragonolobus lectin (LTL) is a plant lectin that specifically recognizes and binds to α-L-fucopyranosyl residues, a sugar structure serving as the key terminal glycosyl group of human blood type O antigen (H antigen). Lotus tetragonolobus lectin exerts macrophage migration inhibitory activity in monomeric form. Lotus tetragonolobus lectin labels and identifies renal proximal tubular epithelial cells to evaluate histopathological changes of sepsis-induced acute kidney injury. Lotus tetragonolobus lectin is applicable to studies in glycobiology, immunology and renal pathology .

HY-176192

SMU-14a	Toll-like Receptor (TLR) NF-κB p38 MAPK ERK IKK TNF Receptor Interleukin Related	Inflammation/Immunology
SMU-14a is a selective Toll-like receptor 3 (TLR3) inhibitor wirh an IC₅₀ of 0.18 μM. SMU-14a reduces phosphorylation of p65, ERK, and TBK1 via NF-κB, MAPK, and IRF3 signaling pathways. SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages, downregulates TNF-α in human peripheral blood monocytes and decreases serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. SMU-14a can be used for the research of acute hepatitis .

HY-107203

Propentofylline HWA 285	Phosphodiesterase (PDE) Adenosine Receptor	Cardiovascular Disease Neurological Disease Cancer
Propentofylline (HWA 285) is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders .

HY-N4022

Hyuganin D Isobocconin; Seravschanin	Others	Inflammation/Immunology
Hyuganin D (Isobocconin) is a Coumarin (HY-N0709) constituent that substantially inhibits LPS (HY-D1056)-induced NO production in mouse peritoneal macrophages .

HY-N3595

Cleomiscosin A	TNF Receptor	Inflammation/Immunology
Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against TNF-alpha secretion of the mouse peritoneal macrophages .

HY-149122

NLRP3-IN-15	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-15 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-15 inhibits IL-1β release with an IC₅₀ of 0.114 μM. NLRP3-IN-15 can be used for the research of inflammation .

HY-138056

7-Acetyl paclitaxel	Microtubule/Tubulin	Others
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC₅₀ ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages .

HY-167715

Traxanox	Histamine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.

HY-P992064

Anti-Mouse IL-4 Antibody (11B.11)	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-4 Antibody (11B.11) is an inhibitor of mouse interleukin-4. Anti-Mouse IL-4 Antibody (11B.11) blocks the chemotactic activity of mouse IL-4 on mouse peritoneal macrophages.

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB₄ and LTC₄, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-149123

NLRP3-IN-16	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-16 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-16 inhibits IL-1β release with an IC₅₀ of 0.065 μM. NLRP3-IN-16 can be used for the research of inflammation .

HY-149121

NLRP3-IN-14	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-14 is a potent and selective NLRP3 inflammasome inhibitor (K_D: 5.87 μM). NLRP3-IN-14 inhibits IL-1β release with an IC₅₀ of 0.131 μM. NLRP3-IN-14 can be used for the research of inflammation .

HY-121365

Forphenicinol	Bacterial	Infection
Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.

HY-130743

Dieugenol Bis-eugenol; Dehydrodieugenol	Parasite	Infection
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC₅₀s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.

HY-N1336

Rubianthraquinone	Others	Others
Rubianthraquinone is a anthraquinone, that can be isolated from the roots of Rubia yunnanensis. Rubianthraquinone inhibits NO production and degranulation .

HY-107203S

Propentofylline-d6 HWA 285-d₆	Isotope-Labeled Compounds Phosphodiesterase (PDE) Adenosine Receptor	Neurological Disease Cancer
Propentofylline-d₆ (HWA 285-d₆) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders .

HY-W040232

Dichlorodipropylstannane	Others	Inflammation/Immunology
Dichlorodipropylstannane is an immunomodulatory agent and significantly reduces the percentage of mouse peritoneal macrophages capable of ingesting yeast.

HY-183934

Anti-inflammatory agent 99	NF-κB JNK ERK p38 MAPK TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 99 is a chalcone derivative. Anti-inflammatory agent 99 inhibits LPS (HY-D1056)-induced NF-κB nuclear translocation and suppress the phosphorylation of JNK, ERK, and p38. Anti-inflammatory agent 99 inhibits the expression of cytoinflammatory factors such as *TNF-α* and IL-6 induced by LPS. Anti-inflammatory agent 99 can be used for the research of LPS-induced septic shock .

HY-N19723

Buddlejasaponin I Verbascosaponin B	COX Lipoxygenase	Inflammation/Immunology
Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE₂, TXB₂, and the 5-LOX metabolite LTC₄ . Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research .

HY-W420454

Danshenspiroketallactone	Others	Inflammation/Immunology Cancer
Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity .

HY-N17448

Fraxinuacidoside	Drug Derivative	Others
Fraxinuacidoside functions as a norditerpene glucopyranoside with a unique carbon skeleton. Fraxinuacidoside can be found in the stem bark of Fraxinus sieboldiana .

Cat. No.	Nombre del producto	Type

HY-NP070

Lotus tetragonolobus lectin LTL	Biochemical Assay Reagents
Lotus tetragonolobus lectin (LTL) is a plant lectin that specifically recognizes and binds to α-L-fucopyranosyl residues, a sugar structure serving as the key terminal glycosyl group of human blood type O antigen (H antigen). Lotus tetragonolobus lectin exerts macrophage migration inhibitory activity in monomeric form. Lotus tetragonolobus lectin labels and identifies renal proximal tubular epithelial cells to evaluate histopathological changes of sepsis-induced acute kidney injury. Lotus tetragonolobus lectin is applicable to studies in glycobiology, immunology and renal pathology .

Lotus tetragonolobus lectin

LTL

Biochemical Assay Reagents

Lotus tetragonolobus lectin (LTL) is a plant lectin that specifically recognizes and binds to α-L-fucopyranosyl residues, a sugar structure serving as the key terminal glycosyl group of human blood type O antigen (H antigen). Lotus tetragonolobus lectin exerts macrophage migration inhibitory activity in monomeric form. Lotus tetragonolobus lectin labels and identifies renal proximal tubular epithelial cells to evaluate histopathological changes of sepsis-induced acute kidney injury. Lotus tetragonolobus lectin is applicable to studies in glycobiology, immunology and renal pathology .

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P992064

Anti-Mouse IL-4 Antibody (11B.11)	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-4 Antibody (11B.11) is an inhibitor of mouse interleukin-4. Anti-Mouse IL-4 Antibody (11B.11) blocks the chemotactic activity of mouse IL-4 on mouse peritoneal macrophages.

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N4022

Hyuganin D Isobocconin; Seravschanin	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Hyuganin D (Isobocconin) is a Coumarin (HY-N0709) constituent that substantially inhibits LPS (HY-D1056)-induced NO production in mouse peritoneal macrophages .

HY-N3595

Cleomiscosin A	Monophenols Classification of Application Fields Lignans Phenols Euphorbiaceae Phenylpropanoids Plants Macaranga adenantha Gagnep. Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor
Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against TNF-alpha secretion of the mouse peritoneal macrophages .

HY-N1336

Rubianthraquinone	Quinones Anthraquinones Rubiaceae Plants Source Classification Rubia yunnanensis Diels	Others
Rubianthraquinone is a anthraquinone, that can be isolated from the roots of Rubia yunnanensis. Rubianthraquinone inhibits NO production and degranulation .

HY-N19723

Buddlejasaponin I Verbascosaponin B	Triterpenes Structural Classification Verbascum songaricum Schrenk Terpenoids Scrophulariaceae Plants Source Classification	COX Lipoxygenase
Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE₂, TXB₂, and the 5-LOX metabolite LTC₄ . Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research .

HY-W420454

Danshenspiroketallactone	Structural Classification Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Plants Source Classification	Others
Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity .

HY-N17448

Fraxinuacidoside	Structural Classification Fraxinus sieboldiana Blume Oleaceae Plants Saccharides Monosaccharides Source Classification	Drug Derivative
Fraxinuacidoside functions as a norditerpene glucopyranoside with a unique carbon skeleton. Fraxinuacidoside can be found in the stem bark of Fraxinus sieboldiana .

Cat. No.	Nombre del producto	Chemical Structure

HY-107203S

Propentofylline-d6
Propentofylline-d₆ (HWA 285-d₆) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders .

Propentofylline-d6

Propentofylline-d₆ (HWA 285-d₆) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders .

Consulta en línea

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Saludo			Country or Region *
Nombre del solicitante *			Nombre de la Organizaciòn *
Department *
Direcciòn del E-mail *			Nombre del producto *
Cat. No.			Requested quantity *
Número de teléfono *
Observaciones

Consulta en línea

Inquiry Information

Nombre del producto:
Cat. No.:
Cantidad:
MCE Japan Authorized Agent:

Mouse Peritoneal Macrophages

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products