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Cat. No.: HY-167715

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Traxanox

Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.

For research use only. We do not sell to patients.

CAS No.: 58712-69-9
Formula: C₁₃H₆ClN₅O₂
Molecular Weight:299.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Traxanox Chemical Structure

CAS No.: 58712-69-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Histamine Receptor Isoforms :

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 58712-69-9
Molecular Weight 299.67
Formula C₁₃H₆ClN₅O₂
SMILES

O=C1C2=CC=CN=C2OC3=C1C=C(C4=NN=NN4)C=C3Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. [Effect of traxanox sodium on inflammatory response] [Content Brief]

[2]. Goto K, et al. Inhibitory effect of traxanox sodium on IgE-mediated histamine release from passively-sensitized mast cells of the rat in vitro. Int Arch Allergy Appl Immunol. 1982;68(4):332-337. [Content Brief]

[3]. Ikegami K, et al. The effects of traxanox sodium of cyclic AMP phosphodiesterase and the concentration of cyclic AMP in the plasma of rats. Chem Pharm Bull (Tokyo). 1983 Feb;31(2):752-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Traxanox

All Histamine Receptor Isoforms

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Traxanox Related Classifications

HY-167715 Related Classifications