2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. Buddlejasaponin I

Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE2, TXB2, and the 5-LOX metabolite LTC4. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research.

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Buddlejasaponin I

Buddlejasaponin I Chemical Structure

CAS No. : 139501-36-3

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Buddlejasaponin I Related Antibodies

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Description

Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE2, TXB2, and the 5-LOX metabolite LTC4[1]. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research[1].

IC50 & Target[1]

5-LOX

 

In Vitro

Buddlejasaponin I potently inhibits LTC4 release from mouse peritoneal macrophages stimulated by the calcium ionophore A23187 (HY-N6687), with an IC50 of 2.4 μM and a 100% inhibition rate at a concentration of 100 μM[1].
Buddlejasaponin I slightly inhibits the release of PGE2 from mouse peritoneal macrophages stimulated by calcium ionophore A23187, with an IC50 of 93 μM and an inhibition rate of 40.4% at a concentration of 100 μM[1].
Buddlejasaponin I inhibits TXB2 release from human platelets stimulated by the calcium ionophore A23187, with an IC50 of 27 μM and an inhibition rate of 76.7% at a concentration of 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Buddlejasaponin I Related Antibodies
In Vivo

Buddlejasaponin I (1 mg/ear; local administration; single dose) exerts a 94.41% inhibitory effect on PMA (HY-18739)-induced ear edema in mice, but does not significantly reduce the associated vascular permeability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (female, 8 weeks old)[1]
Dosage: 1 mg/ear
Administration: topical; single dose
Result: Achieved 94.41% inhibition of PMA-induced ear edema at 3 hours post-PMA.
Exerted only 2.99% inhibition of PMA-induced vascular permeability, which was not a significant effect.
Molecular Weight

1089.26

Formula

C54H88O22
CAS No.
SMILES

C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H]([C@@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)CO)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)C%10([H])[C@@]([C@H](C1)O)(CCC(C)(C%10)C)CO3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Buddlejasaponin I Related Classifications

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Keywords:

Buddlejasaponin I139501-36-3Verbascosaponin BCOXLipoxygenaseCyclooxygenaseLOX5-LOXPGE2mouse peritoneal macrophagesTXB2Verbascum songaricum5-lipoxygenasecyclooxygenaseLTC4human plateletsInhibitorinhibitorinhibit

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