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製品番号: HY-N19723

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Buddlejasaponin I

(別名: Verbascosaponin B)

Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE₂, TXB₂, and the 5-LOX metabolite LTC₄. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research.

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CAS 番号: 139501-36-3
分子式: C₅₄H₈₈O₂₂
分子量:1089.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Buddlejasaponin I 構造式

CAS 番号: 139501-36-3

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE₂, TXB₂, and the 5-LOX metabolite LTC₄^[1]. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research^[1].

IC₅₀ & Target^[1]

5-LOX

COX アイソフォーム固有の製品をすべて表示 :

Lipoxygenase アイソフォーム固有の製品をすべて表示 :

体外実験

Buddlejasaponin I potently inhibits LTC₄ release from mouse peritoneal macrophages stimulated by the calcium ionophore A23187 (HY-N6687), with an IC₅₀ of 2.4 μM and a 100% inhibition rate at a concentration of 100 μM^[1].
Buddlejasaponin I slightly inhibits the release of PGE₂ from mouse peritoneal macrophages stimulated by calcium ionophore A23187, with an IC₅₀ of 93 μM and an inhibition rate of 40.4% at a concentration of 100 μM^[1].
Buddlejasaponin I inhibits TXB₂ release from human platelets stimulated by the calcium ionophore A23187, with an IC₅₀ of 27 μM and an inhibition rate of 76.7% at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Buddlejasaponin I (1 mg/ear; local administration; single dose) exerts a 94.41% inhibitory effect on PMA (HY-18739)-induced ear edema in mice, but does not significantly reduce the associated vascular permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (female, 8 weeks old)^[1]
Dosage:

1 mg/ear
Administration:

topical; single dose
Result:

Achieved 94.41% inhibition of PMA-induced ear edema at 3 hours post-PMA.
Exerted only 2.99% inhibition of PMA-induced vascular permeability, which was not a significant effect.

化学情報

CAS 番号 139501-36-3
分子量 1089.26
分子式 C₅₄H₈₈O₂₂
SMILES

C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H]([C@@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)CO)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)C%10([H])[C@@]([C@H](C1)O)(CCC(C)(C%10)C)CO3
別名

Verbascosaponin B
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bermejo Benito P, et al. In vivo and in vitro antiinflammatory activity of saikosaponins. Life Sci. 1998;63(13):1147-1156. [Content Brief]

[2]. Hartleb I, et al. Triterpenoid saponins from Verbascum songaricum. Phytochemistry. 1995;38(1):221-224. [Content Brief]

Calculators

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Buddlejasaponin I

COX アイソフォーム固有の製品をすべて表示

Lipoxygenase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Buddlejasaponin I 関連分類

HY-N19723 関連分類