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Muscarinic acetylcholine receptors (mAChRs)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (52) Apoptosis (4) Autophagy (5) Biochemical Assay Reagents (1) Calcium Channel (1) Cholinesterase (ChE) (4) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (2) Environmental Pollutants (1) Histamine Receptor (4) IKK (4) Isotope-Labeled Compounds (5) Keap1-Nrf2 (4) mTOR (4) p62 (4) Prolyl Endopeptidase (PREP) (1) Pyroptosis (4) Reference Standards (9)
By Research Areas:	Cancer (10) Cardiovascular Disease (8) Inflammation/Immunology (4) Metabolic Disease (7) Neurological Disease (47)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: mAChR nAChR

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-B1205

Atropine 20+ Cited Publications Tropine tropate; DL-Hyoscyamine	Environmental Pollutants Endogenous Metabolite mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B0298A

Clemastine fumarate 10+ Cited Publications HS-592 fumarate; Meclastine fumarate	Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK	Neurological Disease Metabolic Disease
Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-B0394

Atropine sulfate monohydrate Maximum Cited Publications 25 Publications Verification Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) sulfate monohydrate is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-101372A

Oxotremorine M iodide	mAChR	Neurological Disease
Oxotremorine M iodide is a potent and non-selective **muscarinic acetylcholine receptor (mAChR)** agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms .

HY-B1205A

Atropine sulfate Maximum Cited Publications 25 Publications Verification Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) sulfate is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-17037

Pirenzepine dihydrochloride 5 Publications Verification LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride	mAChR	Metabolic Disease Cancer
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic **acetylcholine receptor**) antagonist, with poor penetration of the blood-brain barrier. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-B0298

Clemastine 10+ Cited Publications HS-592; Meclastine	Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-17037A

Pirenzepine 5 Publications Verification LS 519 free base; Pirenzepin; Gastrozepin	mAChR	Metabolic Disease Cancer
Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic **acetylcholine receptor**) antagonist, with poor penetration of the blood-brain barrier. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells .

HY-B0344

Methscopolamine bromide 1 Publications Verification (-)-Scopolamine methyl bromide; Hyoscine methyl bromide	mAChR	Neurological Disease
Methscopolamine bromide ((-)-Scopolamine methyl bromide; Hyoscine methyl bromide) is a peripherally acting **muscarinic receptor (mAChR)** antagonist that cannot cross the blood-brain barrier. Methscopolamine bromide blocks the muscarinic negative feedback regulation of acetylcholine release from striatal cholinergic terminals, thereby increasing acetylcholine release in the striatum of freely moving rats. Methscopolamine bromide does not induce motor excitation in freely moving rats, nor does it alter the duration of ethanol-induced loss of righting reflex in mice. Methscopolamine bromide fails to antagonize the arecoline-mediated reduction in the duration of ethanol-induced loss of righting reflex in mice .

HY-12157

VU 0238429 1 Publications Verification	mAChR	Others
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 *(mAChR5 or M5), with an EC₅₀* of 1.16 μM.

HY-122743

Iperoxo 2 Publications Verification	mAChR	Neurological Disease
Iperoxo is a potent superagonist of **muscarinic acetylcholine receptor (mAChR)** that activates M1, M2 and M3 receptors with pEC₅₀ of 9.87, 10.1 and 9.78. Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors when labeled with tritium .

HY-112209

VU0467154 5 Publications Verification	mAChR	Neurological Disease
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC₅₀s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

HY-112076

Atropine methyl bromide Methylatropine bromide	mAChR	Neurological Disease
Atropine methyl bromide (Methylatropine bromide), an antagonist of **muscarinic acetylcholine receptors (mAChR)**, is a quaternary ammonium salt of atropine and an active molecule used for pupil dilation during ophthalmic examinations. Due to its high polarity, it is used to relieve pyloric spasm in infants. It is less likely than atropine to cross the central nervous system .

HY-15618

MK-7622 M1 receptor modulator	mAChR Calcium Channel	Neurological Disease
MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC₅₀ = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296)-induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD) .

HY-B2070

Methylbenactyzium Bromide	mAChR	Inflammation/Immunology
Methylbenactyzium Bromide is a **muscarinic acetylcholine receptor** (mAChR) inhibitor.

HY-B1343

Pridinol mesylate	Cholinesterase (ChE)	Neurological Disease
Pridinol mesylate is an orally active, blood-brain permeable, **muscarinic acetylcholine receptor (mAChR)**-directed muscle relaxant. Pridinol mesylate reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol mesylate inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-176200

VU6008055 AF98943	mAChR	Neurological Disease
VU6008055 (AF98943) is a brain-penetrant, orally active and selective muscarinic acetylcholine receptor subtype 4 (mAChR4) activator with human EC₅₀ values of 73.4 nM. VU6008055 potentiates *mAChR4* receptor activity in the presence of acetylcholine, and exhibits no activity at *mAChR1, mAChR3, or mAChR5*. VU6008055 can be used for the research of schizophrenia, parkinson’s disease, alzheimer’s disease .

HY-B0394S

Atropine-d5 Tropine tropate-d₅; DL-Hyoscyamine-d₅	mAChR Autophagy	Neurological Disease
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect .

HY-112076A

Atropine methyl nitrate Methylatropine nitrate	mAChR	Neurological Disease
Atropine methyl bromide (Methylatropine nitrate), an antagonist of **muscarinic acetylcholine receptors (mAChR)**, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine .

HY-B1205R

Atropine (Standard) Tropine tropate (Standard); DL-Hyoscyamine (Standard)	Reference Standards mAChR Endogenous Metabolite	Cardiovascular Disease Neurological Disease
Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-16423

Rapacuronium bromide Org 9487	mAChR	Neurological Disease
Rapacuronium bromide (Org 9487), a non-depolarizing neuromuscular blocker, is an allosteric modulator of **muscarinic acetylcholine receptor (mAChR)** .

HY-117284

Eucatropine	mAChR	Neurological Disease
Eucatropine is a potent **muscarinic acetylcholine receptor (mAChR) inhibitor with an IC₅₀** value of 0.583 μM. Eucatropine is an anticholinergic agent .

HY-119918

Cycrimine	mAChR	Neurological Disease
Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder .

HY-B1205AR

Atropine sulfate (Standard) Tropine tropate sulfate (Standard); DL-Hyoscyamine sulfate (Standard); Sulfatropinol (Standard)	Reference Standards mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-12158

VU0238441	mAChR	Neurological Disease
VU0238441 is a pan **muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC₅₀**s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively .

HY-B1343A

Pridinol	Cholinesterase (ChE)	Neurological Disease
Pridinol is an orally active, blood-brain permeable, **muscarinic acetylcholine receptor (mAChR)**-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-65036

4-Bromo-2-hydroxypyridine 4-Bromo-2-pyridone	Biochemical Assay Reagents Drug Intermediate	Neurological Disease
4-Bromo-2-hydroxypyridine is an intermediate. 4-Bromo-2-hydroxypyridine can be used to synthesize M₁ muscarinic acetylcholine receptor (M₁ mAChR) positive allosteric modulators. 4-Bromo-2-hydroxypyridine can be used in the research of Alzheimer's disease and schizophrenia .

HY-175532

M4 mAChR Modulator-2	mAChR	Neurological Disease
M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC₅₀ = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, κ/δ/μ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a K_i of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) (HY-15084B)-induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia

HY-B1343R

Pridinol mesylate (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Pridinol mesylate (Standard) is the analytical standard of Pridinol mesylate (HY-B1343). This product is intended for research and analytical applications. Pridinol mesylate is an orally active, blood-brain permeable, **muscarinic acetylcholine receptor (mAChR)**-directed muscle relaxant. Pridinol mesylate reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol mesylate inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-W309130

(S)-Tolterodine	mAChR	Neurological Disease
(S)-Tolterodine is a muscarinic acetylcholine receptor (mAChR) inhibitor, with an IC₅₀ of 588 nM .

HY-148961

HTL-9936	mAChR	Neurological Disease
HTL-9936 is a selective M1 muscarinic acetylcholine receptor (M1-mAChR) agonist. HTL-9936 is promising for research of neurodegenerative disorders (e.g., Alzheimer’s) .

HY-131574

Heliosupine N-oxide	mAChR	Neurological Disease
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-160440A

VU6021625	mAChR	Neurological Disease
VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC₅₀ value of 0.44 nM, 57 nM for human M4 and rat M4, respectively .

HY-B1205B

Atropine hydrobromide Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) hydrobromide is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia .

HY-128783

VU0090157	mAChR	Neurological Disease
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease .

HY-B0394R

Atropine sulfate monohydrate (Standard) Tropine tropate sulfate monohydrate (Standard); DL-Hyoscyamine sulfate monohydrate (Standard)	Reference Standards mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-122761

Quifenadine	mAChR	Neurological Disease
Quifenadine (Compound 3a), the hydroxyl-(diphenyl)methyl quinuclidine derivative, is a M3 receptor antagonist with an IC₅₀ value > 1000 nM. Quifenadine can be used for the research of neurological disease .

HY-119333

NNC 11-1607	mAChR	Neurological Disease
NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia .

HY-15116

ONO 1603	Prolyl Endopeptidase (PREP)	Neurological Disease
ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimer's disease by enhancing cholinergic neurotransmission and neuronal function .

HY-W076756

4-Piperidyl N-(2-biphenyl)carbamate	mAChR	Inflammation/Immunology
4-Piperidyl N-(2-biphenyl)carbamate (compound MA) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist. 4-Piperidyl N-(2-biphenyl)carbamate exhibits higher affinity for M₂ and M₃ mAChR than β₂AR (M₂ pK_i = 7.33; M₃ pK_i = 7.51; β₂AR pK_i = 4.94) .

HY-17037R

Pirenzepine dihydrochloride (Standard) LS 519 (Standard); Pirenzepin dihydrochloride (Standard); Gastrozepin dihydrochloride (Standard)	Reference Standards mAChR	Metabolic Disease Cancer
Pirenzepine (dihydrochloride) (Standard) is the analytical standard of Pirenzepine (dihydrochloride). This product is intended for research and analytical applications. Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-17037AR

Pirenzepine (Standard) LS 519 free base (Standard); Pirenzepin (Standard); Gastrozepin (Standard)	mAChR Reference Standards	Metabolic Disease Cancer
Pirenzepine (Standard) is the analytical standard of Pirenzepine. This product is intended for research and analytical applications. Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells .

HY-146102

M1 ligand 1	mAChR	Others
M1 ligand 1 (compound 3b-b) is a muscarinic acetylcholine receptor M1 ligand. M1 ligand 1 is a N-desmethyl congener of arecoline derivative. M1 ligand 1 can be used as PET (positron emission tomography) radiotracer .

HY-17037S1

Pirenzepine-d8 dihydrochloride LS 519-d8 dihydrochloride; Pirenzepin-d8 dihydrochloride; Gastrozepin-d8 dihydrochloride	Isotope-Labeled Compounds mAChR	Cancer
Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic **acetylcholine receptor**) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-112076R

Atropine methyl bromide (Standard) Methylatropine bromide (Standard)	Reference Standards mAChR	Neurological Disease
Atropine methyl bromide (Standard) is the analytical standard of Atropine methyl bromide. This product is intended for research and analytical applications. Atropine methyl bromide (Methylatropine bromide), an antagonist of **muscarinic acetylcholine receptors (mAChR)**, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine .

HY-B1343AS

Pridinol-d5	Cholinesterase (ChE) Isotope-Labeled Compounds	Neurological Disease
Pridinol-d₅ is deuterium labeled Pridinol (HY-B1343A) . Pridinol is an orally active, blood-brain permeable, **muscarinic acetylcholine receptor (mAChR)**-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-17037AS

Pirenzepine-d11 LS 519 free base-d11; Pirenzepin-d11; Gastrozepin-d11	Isotope-Labeled Compounds mAChR	Cancer
Pirenzepine-d₁₁ (LS 519 (free base)-d₁₁; Pirenzepin-d₁₁; Gastrozepin-d₁₁) is the deuterium labeled Pirenzepine (HY-17037A). Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells .

HY-B0298AS

Clemastine-d5 fumarate 1 Publications Verification HS-592-d5 fumarate; Meclastine-d5 fumarate	Isotope-Labeled Compounds Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK	Neurological Disease Metabolic Disease
Clemastine (HS-592; Meclastine)-d₅ fumarate is the deuterium labeled Clemastine fumarate. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-B0298AR

Clemastine fumarate (Standard) HS-592 fumarate (Standard); Meclastine fumarate (Standard)	Reference Standards Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK	Neurological Disease Metabolic Disease
Clemastine (HS-592; Meclastine) fumarate (Standard) is the analytical standard of Clemastine fumarate. This product is intended for research and analytical applications. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-123778

VU6007678	mAChR	Neurological Disease
VU6007678 is a CNS-penetrant muscarinic acetylcholine receptor (mAChR) modulator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-B1205

Atropine 20+ Cited Publications Tropine tropate; DL-Hyoscyamine	Alkaloids Structural Classification Other Alkaloids Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite Source Classification	Environmental Pollutants Endogenous Metabolite mAChR
Atropine (Tropine tropate) is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B1205R

Atropine (Standard) Tropine tropate (Standard); DL-Hyoscyamine (Standard)	Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite Source Classification	Reference Standards mAChR Endogenous Metabolite
Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive **muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀** values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B1205AR

Atropine sulfate (Standard) Tropine tropate sulfate (Standard); DL-Hyoscyamine sulfate (Standard); Sulfatropinol (Standard)	Alkaloids Structural Classification Other Alkaloids Atropa belladonna Linn. Solanaceae Plants Source Classification	Reference Standards mAChR
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Cynoglossumofficinale Linn. Plants Boraginaceae Source Classification	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-B0394R

Atropine sulfate monohydrate (Standard) Tropine tropate sulfate monohydrate (Standard); DL-Hyoscyamine sulfate monohydrate (Standard)	Alkaloids Structural Classification Other Alkaloids Atropa belladonna Linn. Solanaceae Plants Source Classification	Reference Standards mAChR
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

Cat. No.	상품명	Chemical Structure

HY-B0394S

Atropine-d5
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect .

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-B1343AS

Pridinol-d5

Pridinol-d₅ is deuterium labeled Pridinol (HY-B1343A) . Pridinol is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-17037AS

Pirenzepine-d11

Pirenzepine-d₁₁ (LS 519 (free base)-d₁₁; Pirenzepin-d₁₁; Gastrozepin-d₁₁) is the deuterium labeled Pirenzepine (HY-17037A). Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells .

HY-B0298AS

Clemastine-d5 fumarate

1 Publications Verification

Clemastine (HS-592; Meclastine)-d₅ fumarate is the deuterium labeled Clemastine fumarate. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-166417S

Tiotropium-d3 iodide
Tiotropium-d₃ iodide is the deuterium labeled Tiotropium iodide. Tiotropium-d3 iodide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand. Tiotropium-d3 iodide serves as a stable isotope tracer for quantitative analysis .

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