VU6007678 

VU6007678 (compound 18g) is a central nervous system-penetrant muscarinic acetylcholine receptor(mAChR) potentiator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke^[1].

VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) potently acts as a positive allosteric modulator of human M₅ receptors expressed in CHO cells, with an EC₅₀ of 41 nM and a maximum response of 74% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) acts as a positive allosteric modulator of rat M₅ receptors expressed in CHO cells, with an EC₅₀ of 74 nM and a maximum response of 76% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) acts as a positive allosteric modulator of human M₁ receptors expressed in CHO cells, with an EC₅₀ of 1034 nM and a maximum response of 67% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) acts as a positive allosteric modulator of human M₃ receptors expressed in CHO cells, with an EC₅₀ of 466 nM and a maximum response of 71% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) acts as a positive allosteric modulator of rat M₁ receptors expressed in CHO cells, with an EC₅₀ of 904 nM and a maximum response of 69% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) acts as a positive allosteric modulator of rat M₃ receptors expressed in CHO cells, with an EC₅₀ of 772 nM and a maximum response of 51% of acetylcholine's peak activity^[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC₂₀ acetylcholine) weakly acts as a positive allosteric modulator of rat M₄ receptors expressed in CHO cells, with an EC₅₀ of 3913 nM and a maximum response of 49% of acetylcholine's peak activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

484.59

C₂₅H₂₉FN₄O₃S

2222737-15-5

N(C(=O)C1CCN(S(=O)(=O)C=2C=C3C(=CC2)NN=C3)CC1)(CCC)[C@H]4C=5C(CC4)=C(F)C=CC5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bender AM, et al. Discovery and Optimization of Potent and CNS Penetrant M₅-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold. ACS Chem Neurosci. 2018;9(7):1572-1581.  [Content Brief]