VU6007678
VU6007678 is a CNS-penetrant muscarinic acetylcholine receptor (mAChR) modulator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke.
For research use only. We do not sell to patients.
- CAS No.: 2222737-15-5
- Formula: C25H29FN4O3S
- Molecular Weight:484.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
VU6007678 (0-30 μM) potently acts as a positive allosteric modulator of human M5 receptors expressed in CHO cells, with an EC50 of 41 nM and a maximum response of 74% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) acts as a positive allosteric modulator of rat M5 receptors expressed in CHO cells, with an EC50 of 74 nM and a maximum response of 76% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) acts as a positive allosteric modulator of human M1 receptors expressed in CHO cells, with an EC50 of 1034 nM and a maximum response of 67% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) acts as a positive allosteric modulator of human M3 receptors expressed in CHO cells, with an EC50 of 466 nM and a maximum response of 71% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) acts as a positive allosteric modulator of rat M1 receptors expressed in CHO cells, with an EC50 of 904 nM and a maximum response of 69% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) acts as a positive allosteric modulator of rat M3 receptors expressed in CHO cells, with an EC50 of 772 nM and a maximum response of 51% of acetylcholine's peak activity[1].
VU6007678 (0-30 μM) weakly acts as a positive allosteric modulator of rat M4 receptors expressed in CHO cells, with an EC50 of 3913 nM and a maximum response of 49% of acetylcholine's peak activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222737-15-5
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Molecular Weight 484.59
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Formula C25H29FN4O3S
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SMILES
N(C(=O)C1CCN(S(=O)(=O)C=2C=C3C(=CC2)NN=C3)CC1)(CCC)[C@H]4C=5C(CC4)=C(F)C=CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6007678 Related Classifications
HY-123778 Related Classifications
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