Tiotropium-d₃ iodide 

Tiotropium-d₃ iodide is the deuterium labeled Tiotropium iodide. Tiotropium-d3 iodide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand. Tiotropium-d3 iodide serves as a stable isotope tracer for quantitative analysis^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Tiotropium-d3 iodide (100 μg/mL) acts as an effective internal standard for the 2D-UHPLC-MS/MS quantitation of Tiotropium in human plasma, providing consistent recovery and robust matrix effect compensation across normal, hemolyzed, and lipemic plasma lots^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

522.44

C₁₉H₁₉D₃INO₄S₂

412010-61-8

Solid

C[N+]1(C([2H])([2H])[2H])[C@@](C2)([H])[C@](O3)([H])[C@]3([H])[C@]1([H])C[C@@H]2OC(C(C4=CC=CS4)(C5=CC=CS5)O)=O.[I-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Chi J, et al. Ultrasensitive sub-pg/ml determination of tiotropium bromide in human plasma by 2D-UHPLC-MS/MS: challenges and solutions. Bioanalysis. 2016;8(5):385-395.