2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. M3 mAChR agonist 1

M3 mAChR agonist 1 is an M3-preferring M3/M5 mAChR dual positive allosteric modulators (PAM). M3 mAChR agonist 1 shows excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs. M3 mAChR agonist 1 increases the contraction of isolated rat bladder strips by modulating the M3 muscarinic acetylcholine receptor, leading to enhanced signaling pathways. M3 mAChR agonist 1 can be used for the research of endocrinology.

Para uso exclusivo en investigación. No vendemos a pacientes.

M3 mAChR agonist 1

M3 mAChR agonist 1 Estructura química

No. CAS : 1624297-26-2

Tamaño Stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
250 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

M3 mAChR agonist 1 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas mAChR:

Ver todas las isoformas
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

M3 mAChR agonist 1 is an M3-preferring M3/M5 mAChR dual positive allosteric modulators (PAM). M3 mAChR agonist 1 shows excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs. M3 mAChR agonist 1 increases the contraction of isolated rat bladder strips by modulating the M3 muscarinic acetylcholine receptor, leading to enhanced signaling pathways. M3 mAChR agonist 1 can be used for the research of endocrinology[1].

IC50 & Target[1]

mAChR3

 

mAChR5

 

In Vitro

M3 mAChR agonist 1 (compound 9; 1-10 µM) enhances the action of ACh, which is released from nerves through electrical field stimulation (EFS), resulting in increasing contraction of isolated rat bladder strips[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M3 mAChR agonist 1 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-inf T1/2 CLtotal Vss Cmax Tmax F
Rat[1] 0.3 mg/kg i.v. 330.2 ng·h/mL 2.43 h 917.7 mL/h/kg 1.59 L/kg / / /
Rat[1] 1 mg/kg p.o. 208.8 ng·h/mL 2.16 h / / 85.29 ng/mL 0.31 h 19 %
Peso molecular

618.67

Fòrmula

C29H33F3N6O4S
No. CAS
SMILES

O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC=C(OC)C(C(F)(F)F)=C4)=C(CN5[C@H](CC)CCC5)S3)=O)N=C2)CC1)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

M3 mAChR agonist 1 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M3 mAChR agonist 11624297-26-2mAChRMuscarinic acetylcholine receptorM3 muscarinic acetylcholine receptorsmooth muscleInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
M3 mAChR agonist 1
Cat. No.:
HY-131196
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.