2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Eucatropine hydrochloride

Eucatropine hydrochloride is a potent muscarinic acetylcholine receptor (mAChR) inhibitor with an IC50 value of 0.583 μM. Eucatropine hydrochloride acts as an anticholinergic agent. Eucatropine hydrochloride produces behavioral effects via central cholinergic receptive sites in cats.

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Eucatropine hydrochloride

Eucatropine hydrochloride Chemical Structure

CAS No. : 536-93-6

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Eucatropine hydrochloride Related Antibodies

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Description

Eucatropine hydrochloride is a potent muscarinic acetylcholine receptor (mAChR) inhibitor with an IC50 value of 0.583 μM. Eucatropine hydrochloride acts as an anticholinergic agent. Eucatropine hydrochloride produces behavioral effects via central cholinergic receptive sites in cats[1][2].

In Vivo

Eucatropine hydrochloride (0.2-2.0 mg; i.c.v.; single injection) produces mild, short-lasting inconsistent emotional changes, consistent mydriasis and tachypnea, consistent ataxia, no impelling locomotion, and near-undetectable fighting behavior in unanesthetized cats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female (2-4 kg; intracerebroventricular cannula implantation)[1]
Dosage: 0.2 mg, 0.5 mg, 1.0 mg, 2.0 mg
Administration: i.c.v.; single injection
Result: Produced inconsistent emotional effects including miaowing, loud calling, loss of interest of the surroundings, rage, threat, attack, defense, fighting with paws, and flight; no restlessness, impelling locomotion, vacant staring, or apprehension.
Caused consistent mydriasis and tachypnea; inconsistent dyspnea, licking, vomiting, salivation, defecation, and micturition.
Induced consistent ataxia; no scratching, rigidity, weakness with adynamia, myoclonic jerks, or convulsions.
Showed no measurable impelling locomotion at any tested dose.
Caused very short-duration, non-dose-dependent aggressive fighting behavior with mean duration near 0 minutes across all tested doses.
Molecular Weight

327.85

Formula

C17H26ClNO3
CAS No.
SMILES

O=C(OC1CC(C)(C)N(C)C(C)C1)C(O)C2=CC=CC=C2.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eucatropine hydrochloride Related Classifications

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Keywords:

Eucatropine536-93-6mAChRMuscarinic acetylcholine receptorcentral cholinoreceptor modulatorataxiamydriasischolinergic agentcentral cholinoreceptive sitespsychomotor stimulantunanesthetized catstachypneaInhibitorinhibitorinhibit

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