Clemastine-d5 fumarate
Based on 1 publication(s) in Google Scholar
Clemastine (HS-592; Meclastine)-d5 fumarate is the deuterium labeled Clemastine fumarate. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
For research use only. We do not sell to patients.
- Purity: 99.79%
- Formula: C25H25D5ClNO5
- Molecular Weight:464.99
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Clemastine-d5 fumarate
MoreAll Histamine Receptor Isoforms
More
Biological Activity
|
H1 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
Unlabeled Cas 14976-57-9
-
Appearance Solid
-
Molecular Weight 464.99
-
Formula C25H25D5ClNO5
-
Color White to off-white
-
SMILES
CN1[C@@H](CCO[C@](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
-
Synonyms
HS-592-d5 fumarate; Meclastine-d5 fumarate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Biochem Biophys Res Commun
Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice. [Abstract]2023 Jan 15:640:12-20. PMID: 36495605
Solvent & Solubility
DMSO : 100 mg/mL (215.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Zou Y, et al. Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1-mediated autophagy. Br J Pharmacol. 2025;182(12):2730-2753. [Content Brief]
[2]. Kocot J, et al. Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis. J Clin Invest. 2025;135(10):e183941. Published 2025 May 15. [Content Brief]
[3]. Yamazaki R, et al. The potential of repurposing clemastine to promote remyelination. Front Cell Neurosci. 2025;19:1582902. Published 2025 May 7. [Content Brief]
[4]. Myatich A, et al. Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury. Neural Regen Res. 2023;18(5):940-946. [Content Brief]
[5].
Wang X, et al. Clemastine protects against sepsis-induced myocardial injury in vivo and in vitro. Bioengineered. 2022 Mar;13(3):7134-7146.
[Content Brief]
[6]. Liu K, et al. Remyelination-oriented clemastine treatment attenuates neuropathies of optic nerve and retina in glaucoma. Glia. 2024;72(9):1555-1571. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1506 mL | 10.7529 mL | 21.5058 mL | 53.7646 mL |
| 5 mM | 0.4301 mL | 2.1506 mL | 4.3012 mL | 10.7529 mL | |
| 10 mM | 0.2151 mL | 1.0753 mL | 2.1506 mL | 5.3765 mL | |
| 15 mM | 0.1434 mL | 0.7169 mL | 1.4337 mL | 3.5843 mL | |
| 20 mM | 0.1075 mL | 0.5376 mL | 1.0753 mL | 2.6882 mL | |
| 25 mM | 0.0860 mL | 0.4301 mL | 0.8602 mL | 2.1506 mL | |
| 30 mM | 0.0717 mL | 0.3584 mL | 0.7169 mL | 1.7922 mL | |
| 40 mM | 0.0538 mL | 0.2688 mL | 0.5376 mL | 1.3441 mL | |
| 50 mM | 0.0430 mL | 0.2151 mL | 0.4301 mL | 1.0753 mL | |
| 60 mM | 0.0358 mL | 0.1792 mL | 0.3584 mL | 0.8961 mL | |
| 80 mM | 0.0269 mL | 0.1344 mL | 0.2688 mL | 0.6721 mL | |
| 100 mM | 0.0215 mL | 0.1075 mL | 0.2151 mL | 0.5376 mL |
Clemastine-d5 fumarate Related Classifications
HY-B0298AS Related Classifications
Powered by Bioz