Clemastine-d₅ fumarate (Synonyms: HS-592-d5 (fumarate); Meclastine-d5 (fumarate))

Cat. No.: HY-B0298AS Purity: 99.48%: FAQs
Data Sheet SDS COA Handling Instructions

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Clemastine-d₅ (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

For research use only. We do not sell to patients.

Clemastine-d<sub>5</sub> fumarate Chemical Structure

Clemastine-d₅ fumarate Chemical Structure

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1 mg		Check price and availability

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This product is a controlled substance and not for sale in your territory.

Other Forms of Clemastine-d₅ fumarate:

Clemastine fumarate In-stock

1 Publications Citing Use of MCE Clemastine-d₅ fumarate

•Biochem Biophys Res Commun. 2022.

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Purity & Documentation
References
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Description

Clemastine-d₅ (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.99

Formula

C₂₅H₂₅D₅ClNO₅

Appearance

Solid

Color

White to off-white

SMILES

CN1[C@@H](CCO[C@](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (215.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1506 mL	10.7529 mL	21.5058 mL
5 mM	0.4301 mL	2.1506 mL	4.3012 mL
10 mM	0.2151 mL	1.0753 mL	2.1506 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.48%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (258 KB) HNMR (148 KB) RP-HPLC (143 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34. [Content Brief]

[3]. Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1506 mL	10.7529 mL	21.5058 mL	53.7646 mL
	5 mM	0.4301 mL	2.1506 mL	4.3012 mL	10.7529 mL
	10 mM	0.2151 mL	1.0753 mL	2.1506 mL	5.3765 mL
	15 mM	0.1434 mL	0.7169 mL	1.4337 mL	3.5843 mL
	20 mM	0.1075 mL	0.5376 mL	1.0753 mL	2.6882 mL
	25 mM	0.0860 mL	0.4301 mL	0.8602 mL	2.1506 mL
	30 mM	0.0717 mL	0.3584 mL	0.7169 mL	1.7922 mL
	40 mM	0.0538 mL	0.2688 mL	0.5376 mL	1.3441 mL
	50 mM	0.0430 mL	0.2151 mL	0.4301 mL	1.0753 mL
	60 mM	0.0358 mL	0.1792 mL	0.3584 mL	0.8961 mL
	80 mM	0.0269 mL	0.1344 mL	0.2688 mL	0.6721 mL
	100 mM	0.0215 mL	0.1075 mL	0.2151 mL	0.5376 mL

Clemastine-d₅ fumarate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clemastine-d₅HS-592-d5Meclastine-d5Histamine ReceptorAutophagyInhibitorinhibitorinhibit

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Clemastine-d5 fumarate (Synonyms: HS-592-d5 (fumarate); Meclastine-d5 (fumarate))

Other Forms of Clemastine-d5 fumarate:

Clemastine-d5 fumarate Related Antibodies

1 Publications Citing Use of MCE Clemastine-d5 fumarate