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Sphingosine+1-phosphate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Apoptosis (11) Biochemical Assay Reagents (4) Drug Derivative (2) Drug Isomer (1) Drug Metabolite (3) Endogenous Metabolite (2) ERK (2) Fluorescent Dye (1) GSK-3 (2) Interleukin Related (2) Isotope-Labeled Compounds (2) JAK (2) Leukotriene Receptor (2) LPL Receptor (52) Mitochondrial Metabolism (1) P-glycoprotein (2) PI3K (1) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Smo (1) SphK (6) STAT (3) TNF Receptor (2) β-catenin (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (10) Endocrinology (2) Infection (1) Inflammation/Immunology (39) Metabolic Disease (12) Neurological Disease (10)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108496

Sphingosine-1-phosphate 15+ Cited Publications S1P	Endogenous Metabolite LPL Receptor	Inflammation/Immunology Endocrinology Cancer
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .

HY-100675

JTE-013 5+ Cited Publications	LPL Receptor Apoptosis	Cancer
JTE-013 is a potent and specific *S1P₂* (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P₂ with IC₅₀s of 17 nM and 22 nM, respectively ^[1].

HY-19989

MK-571 Maximum Cited Publications 33 Publications Verification L-660711	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release ^[1] .

HY-19989A

MK-571 sodium Maximum Cited Publications 33 Publications Verification L-660711 sodium	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release ^[1] .

HY-101395

W146 5 Publications Verification	LPL Receptor Apoptosis	Metabolic Disease Cancer
W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC₅₀ value of 398 nM.

HY-W008947

SEW2871 5+ Cited Publications	LPL Receptor ERK Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
SEW2871 is an orally active, potent, highly selective *S1P1* (sphingosine-1-phosphate type 1 receptor) agonist, with an EC₅₀ of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses ^[1] .

HY-119401

CAY10444 4 Publications Verification BML-241	LPL Receptor	Cancer
CAY10444 (BML-241) is a **sphingosine-1-phosphate 3 (S1P3)** antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca²⁺ in HeLa cells expressing S1P3 receptors ^[1].

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and **sphingosine-1-phosphate (S1P), and induces cell apoptosis**. Anticancer activity ^[1] .

HY-108491

N,N-Dimethylsphingosine 1 Publications Verification	SphK Apoptosis	Cancer
N,N-Dimethylsphingosine is a *sphingosine* kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research ^[1] .

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective **sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀** of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R ^[1].

HY-110291

A-971432	LPL Receptor	Neurological Disease
A-971432 is a potent, selective and orally active sphingosine-1-phosphate (S1P) receptor 5 agonist with IC₅₀s of .362, >10, 0.006 μM for S1P1, S1P3, S1P5 respectively. A-971432 protects blood–brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimer’s disease or multiple sclerosis ^[1] .

HY-108495

CYM50308 1 Publications Verification ML248	LPL Receptor	Cardiovascular Disease
CYM50308 (ML248) is a potent, selective and high affinity **sphingosine-1-phosphate receptor 4 (S1P₄-R) agonist with an EC₅₀ of 56 nM. CYM50308 displays 37-fold more selective for S1P₄-R** than S1P₅-R. CYM50308 has no activity at S1P₁-R, S1P₂-R and S1P₃-R subtypes at concentrations up to 25 μM ^[1].

HY-13660

Mocravimod hydrochloride 2 Publications Verification KRP-203	LPL Receptor Reactive Oxygen Species (ROS) Akt GSK-3 JAK STAT	Metabolic Disease Inflammation/Immunology Cancer
Mocravimod (hydrochloride) is an orally active **sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod (hydrochloride) preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod (hydrochloride) significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3**. Mocravimod (hydrochloride) retains T cell effector function. Mocravimod (hydrochloride) can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) ^[1] .

HY-109038

Mocravimod 2 Publications Verification KRP-203 free base	LPL Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Akt GSK-3 JAK STAT	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Mocravimod (KRP-203 free base) is a **sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3**. Mocravimod retains T cell effector function. Mocravimod can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) ^[1] .

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d₇	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-14113

2-Acetyl-4-tetrahydroxybutyl imidazole	LPL Receptor	Inflammation/Immunology
2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.

HY-12895

SKI V 1 Publications Verification	SphK PI3K Apoptosis	Cancer
SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC₅₀ of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC₅₀ of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity ^[1] .

HY-162655

SLF80821178 1 Publications Verification	LPL Receptor	Neurological Disease
SLF80821178 is a potent and orally active inhibitor of Sphingosine-1-Phosphate Transporter (Spns2). SLF80821178 inhibits S1P release with an IC₅₀ of 51 nM in HeLa cells and a T_1/2 of 2.4 h in mouse ^[1].

HY-136578

RP101988	LPL Receptor Drug Metabolite	Inflammation/Immunology Cancer
RP101988, the major active metabolite of Ozanimod, is a selective, potent *S1PR1* (sphingosine-1-phosphate receptor 1) agonist, with EC₅₀s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely ^[1].

HY-141630

Sphingosine-1-phosphate (d17:1) D-erythro-Sphingosine-C17-1-phosphate	Drug Derivative	Cancer
Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer ^[1].

HY-101395A

W146 TFA 5 Publications Verification	LPL Receptor Apoptosis	Metabolic Disease Cancer
W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC₅₀ value of 398 nM.

HY-136576

RP101075 1 Publications Verification	LPL Receptor Drug Metabolite	Inflammation/Immunology
RP101075, an active metabolite of Ozanimod, is a potent, orally active *S1PR* (sphingosine-1-phosphate receptor 1) agonist, with an EC₅₀ of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC₅₀=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile ^[1].

HY-D2284

SGPL1 fluorogenic substrate Sphingosine-1-phosphate lyase fluorogenic substrate	Fluorescent Dye	Cancer
SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 ^[1].

HY-164964

TRV045	LPL Receptor	Neurological Disease
TRV045 is a selective *Sphingosine-1-phosphate* subtype 1 receptor agonist with no effect on lymphocyte transport. TRV045 has antiepileptic activity ^[1].

HY-150254A

SLB1122168 formic 1 Publications Verification	LPL Receptor	Inflammation/Immunology
SLB1122168 formic is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 formic inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC₅₀ of 94 nM. SLB1122168 formic induces lymphopenia in circulating lymphocytes in mice and rats ^[1].

HY-115566

S1PL-IN-1	LPL Receptor Smo	Inflammation/Immunology
S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC₅₀ of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC₅₀ of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis ^[1] .

HY-120409

AB1	LPL Receptor Apoptosis	Cancer
AB1 is a highly selective S1P2 receptor antagonist (IC₅₀=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors ^[1].

HY-119221

AUY954	LPL Receptor	Neurological Disease Inflammation/Immunology
AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC₅₀ values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis ^[1] .

HY-139555

Zectivimod	LPL Receptor	Inflammation/Immunology
Zectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases，chronic inflammatory diseases and immunoregulation disorders ^[1].

HY-150254

SLB1122168	LPL Receptor	Inflammation/Immunology
SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC₅₀ of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats ^[1].

HY-148292

*C16-Sphingosine-1-phosphate*	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and also an endogenous ligand for the *EDG/S1P* receptor. C16-Sphingosine-1-phosphate can be used in the research of angiogenesis, inflammation, and cardiovascular diseases ^[1].

HY-147660

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective *S1P1* (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research ^[1] .

HY-W008947R

SEW2871 (Standard)	Reference Standards LPL Receptor ERK Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses ^[1] .

HY-143865

S1PR1 agonist 2	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 2 is a potent agonist of *S1PR1. Sphingosine-1-phosphate* (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) ^[1].

HY-120615

BMS-520	LPL Receptor	Neurological Disease Inflammation/Immunology
BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P₁) agonist with an EC₅₀ of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P₃. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research ^[1].

HY-N15958

*Photoclick sphingosine-1-phosphate*	Biochemical Assay Reagents	Others
Photoclick Sphingosine-1-Phosphate is a clickable sphingolipid that can be used in click chemistry reactions.

HY-172653

Sphingosine-1-phosphate (d18:1) alkyne S1P (d18:1) alkyne	Biochemical Assay Reagents	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Sphingosine-1-phosphate (d18:1) alkyne is an w-alkyne form of sphingosine-1-phosphate. Sphingosine-1-phosphate is a critical regulator of various physiological and pathophysiological processes, such as cancer, atherosclerosis, diabetes and osteroporosis. Sphingosine-1-phosphate can be studied in research for inflammatory diseases, cancer and Alzheimer’s disease ^[1].

HY-172635

Sphingosine-1-phosphate (d18:1(14Z)) S1P (d18:1(14Z))	Biochemical Assay Reagents	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Sphingosine-1-phosphate (d18:1(14Z)) is an atypical sphingolipid that has a cis double bond at the 14-15 position. Sphingosine-1-phosphate is a critical regulator of various physiological and pathophysiological processes, such as cancer, atherosclerosis, diabetes and osteroporosis. Sphingosine-1-phosphate can be studied in research for inflammatory diseases, cancer and Alzheimer’s disease ^[1].

HY-162655A

SLF80821178 hydrochloride	LPL Receptor	Inflammation/Immunology
SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2), that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC₅₀ of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice ^[1].

HY-142032

RBM10-8	LPL Receptor	Inflammation/Immunology
RBM10-8 is irreversible inhibitor of recombinant human sphingosine-1-phosphate lyase (hS1PL) . Sphingosine-1-phosphate (S1P) is a sphingolipid (SL) that acts as a signaling molecule regulating diverse cellular processes such as cell proliferation and differentiation, angiogenesis, immune function, inflammation, and development ^[1].

HY-163128

SPL-IN-1	LPL Receptor	Inflammation/Immunology
SPL-IN-1 (compound C17) is a dual species sphingosine-1-phosphate lyase inhibitor ^[1].

HY-125046

CYM50374	LPL Receptor	Others
CYM50374 is a potent antagonist sphingosine-1-phosphate 4 (S1P4) antagonists, with the IC₅₀ of 34 nM ^[1].

HY-U00366

S1PR1-MO-1	LPL Receptor	Inflammation/Immunology
S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.

HY-110314

CYM50358 hydrochloride	LPL Receptor	Infection
CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection ^[1].

HY-50692

CAY10734	LPL Receptor	Inflammation/Immunology
CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC₅₀ of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant ^[1].

HY-136577

RP101442	LPL Receptor Drug Metabolite	Inflammation/Immunology
RP101442, an active metabolite of Ozanimod, is a selective, potent *S1PR1* (sphingosine-1-phosphate receptor 1) agonist, with EC₅₀s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively ^[1].

HY-W779969

2-Acetyl-4-tetrahydroxybutyl imidazole-13C6	Isotope-Labeled Compounds LPL Receptor	Inflammation/Immunology
2-Acetyl-4-tetrahydroxybutyl imidazole- ¹³C₆ is the ¹³C-labeled 2-Acetyl-4-tetrahydroxybutyl imidazole (HY-14113). 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.

HY-100675R

JTE-013 (Standard)	Reference Standards LPL Receptor Apoptosis	Cancer
JTE-013 (Standard) is the analytical standard of JTE-013. This product is intended for research and analytical applications. JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively ^[1].

HY-125881

ASP1126	LPL Receptor	Inflammation/Immunology
ASP1126 is a selective and orally active **sphingosine-1-phosphate (S1P) agonist, with EC₅₀** values of 7.12 nM, 517 nM for hS1P₁ and hS1P₃, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile ^[1].

HY-143864

S1PR1 agonist 1	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 1 is a potent agonist of *S1PR1. Sphingosine-1-phosphate* (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22) ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P990512

*Anti-Sphingosine-1-phosphate Antibody*	Inhibitory Antibodies	Inflammation/Immunology
Anti-Sphingosine-1-phosphate Antibody is a humanized antibody expressed in CHO cells that targets *Sphingosine-1-phosphate. Anti-Sphingosine-1-phosphate* Antibody is equipped with a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Sphingosine-1-phosphate Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108496

Sphingosine-1-phosphate 15+ Cited Publications S1P	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .

HY-N15958

*Photoclick sphingosine-1-phosphate*	Lipid	Biochemical Assay Reagents
Photoclick Sphingosine-1-Phosphate is a clickable sphingolipid that can be used in click chemistry reactions.

Cat. No.	Product Name	Chemical Structure

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-W779969

2-Acetyl-4-tetrahydroxybutyl imidazole-13C6
2-Acetyl-4-tetrahydroxybutyl imidazole- ¹³C₆ is the ¹³C-labeled 2-Acetyl-4-tetrahydroxybutyl imidazole (HY-14113). 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.

HY-108491S

N,N-Dimethylsphingosine-13C2

N,N-Dimethylsphingosine- ¹³C₂ is the ¹³C-labeled N,N-Dimethylsphingosine (HY-108491). N,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research ^[1].

Cat. No.	Product Name		Classification