1. GPCR/G Protein
  2. LPL Receptor
  3. Mocravimod hydrochloride

Mocravimod hydrochloride (Synonyms: KRP-203)

Cat. No.: HY-13660
Handling Instructions

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist.

For research use only. We do not sell to patients.

Mocravimod hydrochloride Chemical Structure

Mocravimod hydrochloride Chemical Structure

CAS No. : 509088-69-1

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Description

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].

IC50 & Target

S1PR1[1]

In Vivo

Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R−/− Mice[1].
Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2].

Animal Model: Inbred male DA (MHC haplotype: RT1a) rats[2]
Dosage: 0.1 and 1 mg/kg
Administration: Orally; daily; for 100 days
Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.
Molecular Weight

480.45

Formula

C₂₄H₂₇Cl₂NO₃S

CAS No.

509088-69-1

SMILES

OCC(CCC1=CC=C(SC2=CC=CC(OCC3=CC=CC=C3)=C2)C=C1Cl)(N)CO.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MocravimodKRP-203KRP203KRP 203LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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Mocravimod hydrochloride
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HY-13660
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