1. GPCR/G Protein
  2. LPL Receptor

Siponimod (Synonyms: BAF-312)

Cat. No.: HY-12355 Purity: 98.61%
Handling Instructions

Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively). Used to treat adult multiple sclerosis.

For research use only. We do not sell to patients.

Siponimod Chemical Structure

Siponimod Chemical Structure

CAS No. : 1230487-00-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 68 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 260 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
1 g USD 2000 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively). Used to treat adult multiple sclerosis.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (58.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9357 mL 9.6787 mL 19.3573 mL
5 mM 0.3871 mL 1.9357 mL 3.8715 mL
10 mM 0.1936 mL 0.9679 mL 1.9357 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

516.60

Formula

C₂₉H₃₅F₃N₂O₃

CAS No.

1230487-00-9

SMILES

O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.61%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Siponimod
Cat. No.:
HY-12355
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Siponimod

Cat. No.: HY-12355