1. GPCR/G Protein
  2. LPL Receptor

Siponimod (Synonyms: BAF-312)

Cat. No.: HY-12355 Purity: 98.61%
Handling Instructions

Siponimod(BAF-312) is a potent and selective S1P1 receptor agonist with EC50 of 0.4 nM; >10,000 fold potency for S1P3.

For research use only. We do not sell to patients.
Siponimod Chemical Structure

Siponimod Chemical Structure

CAS No. : 1230487-00-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 130 In-stock
5 mg USD 114 In-stock
10 mg USD 174 In-stock
50 mg USD 600 In-stock
100 mg USD 958 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Siponimod(BAF-312) is a potent and selective S1P1 receptor agonist with EC50 of 0.4 nM; >10,000 fold potency for S1P3. IC50 value: 0.4 nM(EC50) [1] Target: S1P1 agonist Siponimod is extensively bound to rat, dog, monkey, and human plasma proteins (>99.9%). It shows high and passive permeability in a Caco-2 human cell permeability assay with no transporter-mediated efflux observed at the test concentrations of 0.5–50 μM. Siponimod is moderately distributed to tissues as compared to total body water following intravenous administration to rat (Vss = 2.15 ± 0.31 L/kg) and monkey (Vss = 2.12 ± 0.12 L/kg).

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9357 mL 9.6787 mL 19.3573 mL
5 mM 0.3871 mL 1.9357 mL 3.8715 mL
10 mM 0.1936 mL 0.9679 mL 1.9357 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

516.6

Formula

C₂₉H₃₅F₃N₂O₃

CAS No.

1230487-00-9

SMILES

O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.61%

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Product Name:
Siponimod
Cat. No.:
HY-12355
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