Siponimod hemifumarate (Synonyms: BAF-312 hemifumarate)

Cat. No.: HY-12355A: FAQs
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Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC₅₀s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research.

For research use only. We do not sell to patients.

Siponimod hemifumarate Chemical Structure

CAS No. : 1234627-85-0

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Other In-stock Forms of Siponimod hemifumarate:

Siponimod

Other Forms of Siponimod hemifumarate:

Siponimod In-stock
Siponimod-d₁₁ Get quote

6 Publications Citing Use of MCE Siponimod hemifumarate

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•Related Small Molecules:

•Related Proteins:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

S1PR1

0.39 nM (EC₅₀)

S1PR5

0.98 nM (EC₅₀)

S1PR4

750 nM (EC₅₀)

S1PR3

>1000 nM (EC₅₀)

S1PR2

>10000 nM (EC₅₀)

Clinical Trial

Molecular Weight

574.63

Formula

C₂₉H₃₅F₃N₂O₃.1/2C₄H₄O₄

CAS No.

1234627-85-0

SMILES

O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O.OC(/C=C/C(O)=O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. [Content Brief]

[2]. McGinley M, et al. Prospects of siponimod in secondary progressive multiple sclerosis. Ther Adv Neurol Disord. 2018 Jul 17;11:1756286418788013. [Content Brief]

[3]. Behrangi N, et al. Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action. Cells. 2019 Jan 7;8(1):24. [Content Brief]

Siponimod hemifumarate Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siponimod hemifumarate1234627-85-0BAF-312 hemifumarateLPL ReceptorLysophospholipid Receptormultiple sclerosisneurodegenerationinflammationsiponimodprogressiveS1P receptorS1P1 agonistlymphocytesInhibitorinhibitorinhibit

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