1. GPCR/G Protein
  2. LPL Receptor
  3. CYM50260

CYM50260 

Cat. No.: HY-108494 Purity: >99.0%
Handling Instructions

CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

For research use only. We do not sell to patients.

CYM50260 Chemical Structure

CYM50260 Chemical Structure

CAS No. : 1355026-60-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 336 In-stock
Estimated Time of Arrival: December 31
1 mg USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 435 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Description

CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].

IC50 & Target

EC50: 45 nM (S1P4-R)[1]

In Vitro

CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1].
CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].

Molecular Weight

350.60

Formula

C₁₄H₁₁Cl₃FNO₂

CAS No.

1355026-60-6

SMILES

FCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CYM50260CYM 50260CYM-50260LPL ReceptorLysophospholipid ReceptorS1P4-RSARanalysissyntheticplateletaggregationPDGF-ABHSP27Inhibitorinhibitorinhibit

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Product name:
CYM50260
Cat. No.:
HY-108494
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