1. GPCR/G Protein
  2. LPL Receptor

Ponesimod (Synonyms: ACT-128800)

Cat. No.: HY-10569 Purity: 99.53%
Handling Instructions

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator.

For research use only. We do not sell to patients.

Ponesimod Chemical Structure

Ponesimod Chemical Structure

CAS No. : 854107-55-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 852 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator. IC50 value: Target: S1P1 agonist in vitro: Ponesimod activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity [1]. in vivo: Oral administration of ponesimod to rats led to a dose-dependent decrease of blood lymphocyte count. After discontinuation of dosing, blood lymphocyte count returned to baseline within 48 h. Ponesimod prevented edema formation, inflammatory cell accumulation, and cytokine release in the skin of mice with delayed-type hypersensitivity [1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1693 mL 10.8467 mL 21.6934 mL
5 mM 0.4339 mL 2.1693 mL 4.3387 mL
10 mM 0.2169 mL 1.0847 mL 2.1693 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

460.97

Formula

C₂₃H₂₅ClN₂O₄S

CAS No.

854107-55-4

SMILES

O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[[email protected]](O)CO)C(Cl)=C3)=N/CCC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.53%

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× = ×
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Product Name:
Ponesimod
Cat. No.:
HY-10569
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Ponesimod

Cat. No.: HY-10569