Ponesimod-d7
Based on 1 Customer Validation
Ponesimod-d7 (ACT-128800-d7) is the deuterium-labeled Ponesimod (HY-10569). Ponesimod-d7 (ACT-128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod-d7 activates S1P1-mediated signal transduction with high potency (EC50=5.7 nM). Ponesimod-d7 can protect against lymphocyte-mediated tissue inflammation.
For research use only. We do not sell to patients.
- Purity: 96.50%
- Formula: C23H18D7ClN2O4S
- Molecular Weight:468.02
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 854107-55-4
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Appearance Solid
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Molecular Weight 468.02
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Formula C23H18D7ClN2O4S
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Color Light yellow to yellow
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SMILES
O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])([2H])[2H])/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC
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Synonyms
ACT-128800-d7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (213.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (245 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1367 mL | 10.6833 mL | 21.3666 mL | 53.4165 mL |
| 5 mM | 0.4273 mL | 2.1367 mL | 4.2733 mL | 10.6833 mL | |
| 10 mM | 0.2137 mL | 1.0683 mL | 2.1367 mL | 5.3417 mL | |
| 15 mM | 0.1424 mL | 0.7122 mL | 1.4244 mL | 3.5611 mL | |
| 20 mM | 0.1068 mL | 0.5342 mL | 1.0683 mL | 2.6708 mL | |
| 25 mM | 0.0855 mL | 0.4273 mL | 0.8547 mL | 2.1367 mL | |
| 30 mM | 0.0712 mL | 0.3561 mL | 0.7122 mL | 1.7806 mL | |
| 40 mM | 0.0534 mL | 0.2671 mL | 0.5342 mL | 1.3354 mL | |
| 50 mM | 0.0427 mL | 0.2137 mL | 0.4273 mL | 1.0683 mL | |
| 60 mM | 0.0356 mL | 0.1781 mL | 0.3561 mL | 0.8903 mL | |
| 80 mM | 0.0267 mL | 0.1335 mL | 0.2671 mL | 0.6677 mL | |
| 100 mM | 0.0214 mL | 0.1068 mL | 0.2137 mL | 0.5342 mL |
Ponesimod-d7 Related Classifications
HY-10569S1 Related Classifications
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