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  2. LPL Receptor
  3. CYM50308

CYM50308 

Cat. No.: HY-108495 Purity: >99.0%
Handling Instructions

CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM.

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CYM50308 Chemical Structure

CYM50308 Chemical Structure

CAS No. : 1345858-76-5

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10 mM * 1  mL in DMSO USD 294 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Description

CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1].

IC50 & Target

EC50: 56 nM (S1P4-R), 2100 nM (S1P5-R)[1]

In Vitro

The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1].

Molecular Weight

405.46

Formula

C₂₀H₂₁F₂N₃O₂S

CAS No.

1345858-76-5

SMILES

O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CYM50308CYM 50308CYM-50308LPL ReceptorLysophospholipid ReceptorPotentselectiveS1P4-Rsphingosine-1-phosphatereceptorInhibitorinhibitorinhibit

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CYM50308
Cat. No.:
HY-108495
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