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  2. LPL Receptor
  3. CYM50308

CYM50308 (Synonyms: ML248)

Cat. No.: HY-108495 Purity: >99.0%
Handling Instructions

CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM.

For research use only. We do not sell to patients.

CYM50308 Chemical Structure

CYM50308 Chemical Structure

CAS No. : 1345858-76-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 294 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1].

IC50 & Target

EC50: 56 nM (S1P4-R), 2100 nM (S1P5-R)[1]

In Vitro

The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

405.46

Formula

C₂₀H₂₁F₂N₃O₂S

CAS No.

1345858-76-5

SMILES

O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12 mg/mL (29.60 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4663 mL 12.3317 mL 24.6633 mL
5 mM 0.4933 mL 2.4663 mL 4.9327 mL
10 mM 0.2466 mL 1.2332 mL 2.4663 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 3 mg/mL (7.40 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (7.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

CYM50308ML248CYM 50308CYM-50308ML 248ML-248LPL ReceptorLysophospholipid ReceptorPotentselectiveS1P4-Rsphingosine-1-phosphatereceptorInhibitorinhibitorinhibit

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Product Name:
CYM50308
Cat. No.:
HY-108495
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